Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Regeneration And Healing Of Bone And Cartilage In Type-1 And Type-2 Diabetes: The Effects Of Insulin, Sümeyya Akyol, Mehmet Aki̇f Güleç, Hi̇lmi̇ Demi̇ri̇n, Ömer Akyol
Regeneration And Healing Of Bone And Cartilage In Type-1 And Type-2 Diabetes: The Effects Of Insulin, Sümeyya Akyol, Mehmet Aki̇f Güleç, Hi̇lmi̇ Demi̇ri̇n, Ömer Akyol
Turkish Journal of Biology
Increased fragility of long bones and delay in fracture healing in adults as well as skeletal development disorders in children are thought to be associated with endochondral ossification problems. The extracellular matrix (ECM) of cartilage is absorbed during endochondral ossification. During the recovery process from damage, chondrocytes undergo hypertrophy and increase their cell volume; on the other hand, it is also necessary to digest the ECM elements around the cells. Recent research on the proteolytic enzymes in ECM assumed to be responsible for the digestion is connected to proteinases digesting type II collagen and aggrecan. ADAMTS1, 4, and 5 are …
Emerging Roles Of Adamts Metalloproteinases In Regenerativemedicine And Restorative Biology, Ferah Armutcu, Kadi̇r Demi̇rcan
Emerging Roles Of Adamts Metalloproteinases In Regenerativemedicine And Restorative Biology, Ferah Armutcu, Kadi̇r Demi̇rcan
Turkish Journal of Biology
ADAMTS (a disintegrin and metalloprotease with thrombospondin motifs) proteinases degrade proteoglycans and thereby have the potential to alter tissue architecture and regulate cellular function. Recent studies about the roles of these enzymes have produced new perspectives for the molecular mechanisms behind regenerative biology with clinical potential to generate therapeutic targets to resolve tissue injury. ADAMTS enzymes play an important role in the turnover of extracellular matrix proteins in various tissues and their dysregulation has been implicated in disease-related processes such as inflammation and fibrosis. Increasing evidence indicates that they may be of key significance in the physiological and pathological central …