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Genotoxic And Mutagenic Effects Of Aqueous Extract From Aerial Parts Of Achillea Teretifolia, Di̇lek Akyil, Sedat Oktay, Recep Li̇man, Yasi̇n Eren, Muhsi̇n Konuk
Genotoxic And Mutagenic Effects Of Aqueous Extract From Aerial Parts Of Achillea Teretifolia, Di̇lek Akyil, Sedat Oktay, Recep Li̇man, Yasi̇n Eren, Muhsi̇n Konuk
Turkish Journal of Biology
Genotoxic and mutagenic effects of aqueous extract from aerial parts of Achillea teretifolia (At-ext) were investigated using both Allium cepa root meristematic cells and a short-term mutation assay in Salmonella typhimurium with TA98 and TA100 strains in the presence or absence of S9 mix, respectively. In the Allium tests, EC_{50} value was determined as 50 g/L, and 0.5 × EC_{50}, EC_{50}, and 2 × EC_{50} concentrations of At-ext were applied to onion tuber roots. Methyl methane sulfonate (MMS, 10 ppm) and distilled water were used as positive and negative controls, respectively. The mitotic index (MI) increased in all concentrations in …
Genotoxicity Of Bovine Bone-Derived Microhydroxyapatite (Boneplus-Xs), Mehmet Topaktaş, Erman Sali̇h İsti̇fli̇, Mehmet Büyükleyla, Hasan Basri̇ İla, Tuba Canitezer, Mehmet Kürkçü
Genotoxicity Of Bovine Bone-Derived Microhydroxyapatite (Boneplus-Xs), Mehmet Topaktaş, Erman Sali̇h İsti̇fli̇, Mehmet Büyükleyla, Hasan Basri̇ İla, Tuba Canitezer, Mehmet Kürkçü
Turkish Journal of Biology
The aim of this study was to evaluate the genotoxic effect of a bovine bone-derived hydroxyapatite (HA), Boneplus-xs (B-P-XS). The genotoxicity of B-P-XS was investigated by examining the potential of the xenograft (B-P-XS) to induce gene mutation (evaluated using the Ames test), in vitro chromosome aberration (CA), and sister chromatid exchange (SCE) with tests in cultured human peripheral lymphocytes. Counts of reverse mutations in Salmonella typhimurium TA98 and TA100 strains were not found to be significantly increased after treatment with B-P-XS (P > 0.05). The presence of B-P-XS in peripheral blood culture for 24 and 48 h did not lead to …