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A Stereoscopic Scanning Electron Microscope Study Of Pulmonary Hypoplasia In Chondrodystrophic Mice, W. Bradford Hepworth, Robert E. Seegmiller
A Stereoscopic Scanning Electron Microscope Study Of Pulmonary Hypoplasia In Chondrodystrophic Mice, W. Bradford Hepworth, Robert E. Seegmiller
Scanning Microscopy
Pulmonary hypoplasia is a life threatening condition in newborns resulting from a generalized underdevelopment of the lungs. The lung disorder is usually secondary to conditions outside the lung such as thoracic volume reduction. The precise mechanism by which thoracic volume reduction prevents normal lung development and growth is unknown. As a model for human pulmonary hypoplasia associated with lethal skeletal dysplasia, a stereoscopic SEM study of chondrodystrophic (cho) fetal mouse lungs fixed by intratracheal instillation with 3% glutaraldehyde was conducted. In comparison with lungs of phenotypically normal littermates, the mutant's lungs appeared unaffected with respect to structure of major …
Scanning Electron Microscopy Of Lung Following Alpha Irradiation, C. L. Sanders, K. E. Lauhala, K. E. Mcdonald
Scanning Electron Microscopy Of Lung Following Alpha Irradiation, C. L. Sanders, K. E. Lauhala, K. E. Mcdonald
Scanning Microscopy
Pulmonary aggregation of inhaled 239PuO2 particles leads to a cellular evolution of focal inflammation, fibrosis, epithelial dysplasia and lung tumor formation. Female Wistar rats were exposed to an aerosol of high-fired 239PuO2 (initial lung burden, 3.9 kBq) and the lungs examined at intervals from 1 day to 700 days after exposure by light and scanning electron microscopy and autoradiography. Peribronchiolar Pu particle aggregation increased with time, resulting in well-defined focal inflammatory lesions after 120 days and fibrotic lesions after 180 days. A generalized hypertrophy and hyperplasia of nonciliated bronchiolar cells was seen at 15 days and …