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Biology

Journal

1989

Hypercalcemia

Articles 1 - 2 of 2

Full-Text Articles in Life Sciences

Strontium And Bromide As Tracers In X-Ray Microanalysis Of Biological Tissue, Joanna Wroblewski, Samuel Sagström, Helmy Mulders, Godfried M. Roomans Oct 1989

Strontium And Bromide As Tracers In X-Ray Microanalysis Of Biological Tissue, Joanna Wroblewski, Samuel Sagström, Helmy Mulders, Godfried M. Roomans

Scanning Microscopy

Since energy dispersive X-ray microanalysis cannot distinguish between isotopes of the same element, alternative methods have to be used to get information similar to that obtained in experiments with radioactive tracers. In the present study, strontium was used as a tracer for calcium, and bromide as a tracer for chloride. Rats were injected with strontium chloride in vivo, and the uptake of strontium in the acinar cells of the submandibular gland was studied. Eventually a Sr/Ca ratio of 0.3 was reached. In some animals, secretion of mucus had been elicited by stimulation with isoproterenol 4 h prior to injection …


X-Ray Microanalysis Of Mammalian Salivary Glands, Godfried M. Roomans, R. Margareta Müller, Samuel Sagström, Gun-Britt Sagulin, Susan M. Scarlett, Joanna Wroblewski, Maria Albertsson Mar 1989

X-Ray Microanalysis Of Mammalian Salivary Glands, Godfried M. Roomans, R. Margareta Müller, Samuel Sagström, Gun-Britt Sagulin, Susan M. Scarlett, Joanna Wroblewski, Maria Albertsson

Scanning Microscopy

X-ray microanalysis was used to study the elemental composition of major salivary glands in rat and man. The elemental composition of the acinar cells is influenced by a variety of factors. Stimulation of fluid secretion by cholinergic, α-adrenergic or peptidergic agonists leads to a sustained increase of the Na/K ratio. The elemental composition and ultrastructure of the acinar cells of rat submandibular gland, as well as flow rate and composition of pilocarpinestimulated submandibular saliva are significantly affected by thyroxine, but less by the synthetic glucocorticoid dexamethasone. Hypercalcemia (induced by chronic vitamin D treatment) as well as hypocalcemia (induced by calcitonin) …