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Full-Text Articles in Life Sciences
The Mrna/Protein Relationship Is Fluid And Changes Across Tissue And Diseased States, Jose Humberto Giraldez Chavez, Sam Payne
The Mrna/Protein Relationship Is Fluid And Changes Across Tissue And Diseased States, Jose Humberto Giraldez Chavez, Sam Payne
Library/Life Sciences Undergraduate Poster Competition 2022
- Cancer is a dysregulated cell
- Molecular typing via DNA/RNA/protein
- Is RNA a proxy for cell?
Eeg As Successful Diagnostic Tool For Immune Effector Cell Associated Neurotoxicity Syndrome, Daniel Jones, Christine Eckhardt, Haoqi Sun, Ryan Tesh, Brandon Westover
Eeg As Successful Diagnostic Tool For Immune Effector Cell Associated Neurotoxicity Syndrome, Daniel Jones, Christine Eckhardt, Haoqi Sun, Ryan Tesh, Brandon Westover
Library/Life Sciences Undergraduate Poster Competition 2022
CAR T cell therapy was first proven effective in 20131 for the treatment of certain cancer s . However, its widespread adoption is still hindered by side effects like immune effector cell associated neurotoxicity syndrome (ICANS). Current research aims to better predict, diagnose, and treat ICANS so that CAR T cell therapy can be more widely applied. Although prior studies have attempted to identify an objective biomarker of ICANS2 , current practice relies on clinical assessment to diagnose ICANS. We hypothesize that qualitative features of the EEG may be utilized to develop a physiological grading system of the …
Effect Of Cyclooxygenase-2 Glycosylation On Downstream Expression Of E-Cadherin And Β-Catenin In Mcf-7 Breast Cancer Cells, Genna Roan, Grace Alexander, Klarisse Cruz, Janelle Nguyen, Mary B. Sevigny
Effect Of Cyclooxygenase-2 Glycosylation On Downstream Expression Of E-Cadherin And Β-Catenin In Mcf-7 Breast Cancer Cells, Genna Roan, Grace Alexander, Klarisse Cruz, Janelle Nguyen, Mary B. Sevigny
Natural Sciences and Mathematics | Faculty Research Posters
Cyclooxygenase-2 (COX-2) is an enzyme that helps catalyze the formation of prostaglandins, which promote inflammation, pain, and fever and maintain other normal physiological functions throughout the body. However, the overexpression of COX-2 has been found to play a role in various diseases including breast cancer. COX-2 exists as two major glycoforms— 72 kDa and 74 kDa— due to the glycosylation site Asn580 which is glycosylated 50% of the time. Past studies from our lab have shown that this glycosylation regulates COX-2 protein turnover in the cell3. The proteins E-cadherin— a tumor suppressor— and β-catenin— a tumor driver— can be regulated …
Evaluating Human Cell Survival And Dna Damage After Exposure To Various Amounts Of Chlorine Dioxide And Exploring Its Use As A Potential Cancer Chemotherapy Agent, Niuska Mariana Alvarez Fuenmayor
Evaluating Human Cell Survival And Dna Damage After Exposure To Various Amounts Of Chlorine Dioxide And Exploring Its Use As A Potential Cancer Chemotherapy Agent, Niuska Mariana Alvarez Fuenmayor
SURF - Summer Undergraduate Research Fellowship Projects
Chlorine Dioxide (ClO2) is a synthetic, green-yellowish gas with a chlorine-like, irritating odor that is used for the treatment of drinking water and food preservation. The aim of this study was to evaluate the genotoxic potential of the chlorine dioxide in mammalian cells and to determine what dose of ClO2 is tolerable by normal cells and cells with aberrant DNA repair genes. Human and mouse embryonic cells were treated with various ClO2 dilutions ranging from 2.5 mM to 25 mM. The cell viability and metabolic activity was determined via MTT, a colorimetric assay. Human HEK293 cells …