Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Developing A Label Propagation Approach For Cancer Subtype Identification Problem, Pinar Güner, Burcu Güngör, Mustafa Coşkun
Developing A Label Propagation Approach For Cancer Subtype Identification Problem, Pinar Güner, Burcu Güngör, Mustafa Coşkun
Turkish Journal of Biology
Cancer is a disease in which abnormal cells grow uncontrollably and invade other tissues. Several types of cancer have various subtypes with different clinical and biological implications. Based on these differences, treatment methods need to be customized. The identification of distinct cancer subtypes is an important problem in bioinformatics, since it can guide future precision medicine applications. In order to design targeted treatments, bioinformatics methods attempt to discover common molecular pathology of different cancer subtypes. Along this line, several computational methods have been proposed to discover cancer subtypes or to stratify cancer into informative subtypes. However, existing works do not …
Doxorubicin-Induced Transcriptome Meets Interactome: Identification Of New Drug Targets, Hi̇lal Taymaz-Ni̇kerel
Doxorubicin-Induced Transcriptome Meets Interactome: Identification Of New Drug Targets, Hi̇lal Taymaz-Ni̇kerel
Turkish Journal of Biology
The working mechanism of the chemotherapeutic drug doxorubicin, which is frequently used in cancer treatment, its effects on cell metabolism, and pathways activated solely by doxorubicin are not fully known. Understanding these principles is important both in improving existing therapies and in finding new drug targets. Here, I describe a systems-biology approach to find a generalizable working principle for doxorubicin by superimposition of human interactome over gene datasets commonly expressed among various cancer types. The common ?in at least two different diseases?transcriptional response of distinctive cancer cell lines to doxorubicin was reflected via 199 significantly and differentially expressed genes, mostly …