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Full-Text Articles in Life Sciences
Investigating The Regulation And Role Of P38 Mapk In Collagen-Related Limb Girdle Muscular Dystrophy, Briseida Oceguera-Perez
Investigating The Regulation And Role Of P38 Mapk In Collagen-Related Limb Girdle Muscular Dystrophy, Briseida Oceguera-Perez
Theses and Dissertations
Aging is an expected and normal process across living organisms. It is characterized as a loss of stress resistance, degeneration of tissues, and decline in motor function that happen gradually across lifespan. Susceptibility to neurodegenerative and dystrophic conditions also increase, and unlike aging, are not a normal aspect of lifespan. Discerning the difference between normal and aberrant aging states will give insight into the mechanisms behind the progressive dysfunction shared among organisms. Previous work in our lab has shown that the aging gene p38 MAPK in Drosophila melanogaster plays a significant role in the aging process through its downstream effects …
Determining The Relationship Between Aging And Oxidative Stress In A Drosophila Melanogaster P38 Kb Framework, Aleksandra J. Majewski
Determining The Relationship Between Aging And Oxidative Stress In A Drosophila Melanogaster P38 Kb Framework, Aleksandra J. Majewski
Theses and Dissertations
Aging is inevitable for all organisms and can be characterized by degeneration of tissue, adecrease in motor function, and impaired stress response. In humans, it is often accompanied by an increased propensity for age related diseases. While all adults experience biological aging (senescence) not all adults experience age-associated disease. Thus, we claim these are not normal prospects of aging. Although the implications of aging are well understood, the molecular underpinnings for these processes remain elusive. As advances in medical science have been successful at prolonging lifespan, they concurrently extend the amount of time spend in diseased states. If we wish …
Establishing The Microcrustacean Daphnia As A Model System For Research On Aging, Charles Andrew Shumpert
Establishing The Microcrustacean Daphnia As A Model System For Research On Aging, Charles Andrew Shumpert
Theses and Dissertations
Aging is a ubiquitous process pertaining to all biological systems around the planet. Although much has been learned from studies so far on the molecular mechanisms that lead to aging, a complete understanding of a healthy life span and longevity still eludes us. In this dissertation, we will examine the use of a freshwater microcrustacean Daphnia as a model system for studies on the biology of aging. The Introduction chapter presents a review of the general molecular alterations associated with cellular and organismal aging, and discusses the core model organisms currently used to study the aging process. The introduction chapter …