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A Study Protocol To Prepare An Rbd Protein For Vaccine Against Covid-19, Z.M.G. Sarwar Jahangir, Arleta Helena Marnik
A Study Protocol To Prepare An Rbd Protein For Vaccine Against Covid-19, Z.M.G. Sarwar Jahangir, Arleta Helena Marnik
Publications and Research
Background: SARS-CoV-2 pandemic is a global threat to humans and the world’s economy. Effective and safe vaccines against this virus are essential to control and eradicate the pandemic. The currently applied vaccines carry SARS-CoV-2 spike-protein mRNA/cDNA. These vaccines go through several cellular processes in the recipients for producing antigens. On the contrary, the SARS-CoV-2 RBD (receptor binding domain)-protein is an antigen. It will directly stimulate antibody production against SARS-CoV-2. Hence, we propose to produce SARS-CoV-2 RBD-protein as a fast acting, effective and safe vaccine.
Methods: We propose to reconstruct a plasmid carrying three types of DNA sequences: RBD cDNA, FP …