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Full-Text Articles in Life Sciences
Chronic Pulmonary Cavitary Tuberculosis In Rabbits: A Failed Host Immune Response, Selvakumar Subbian, Liana Tsenova, Guibin Yang, Paul O'Brien, Sven Parsons, Blas Peixoto, Leslie Taylor, Dorothy Fallows, Gilla Kaplan
Chronic Pulmonary Cavitary Tuberculosis In Rabbits: A Failed Host Immune Response, Selvakumar Subbian, Liana Tsenova, Guibin Yang, Paul O'Brien, Sven Parsons, Blas Peixoto, Leslie Taylor, Dorothy Fallows, Gilla Kaplan
Publications and Research
The molecular determinants of the immune response to Mycobacterium tuberculosis HN878 infection in a rabbit model of pulmonary cavitary tuberculosis were studied. Aerosol infection of rabbits resulted in a highly differentially expressed global transcriptome in the lungs at 2 weeks, which dropped at 4 weeks and then gradually increased. While IFNγ was progressively upregulated throughout the infection, several other genes in the IFNγ network were not. T-cell activation network genes were gradually upregulated and maximally induced at 12 weeks. Similarly, the IL4 and B-cell activation networks were progressively upregulated, many reaching high levels between 12 and 16 weeks. Delayed peak …