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Full-Text Articles in Life Sciences
Exploring The Anticancer Mechanism Of Thienopyrazole Derivative Tpz-1 In Acute Myeloid Leukemia, Jessica Dyanne Hess
Exploring The Anticancer Mechanism Of Thienopyrazole Derivative Tpz-1 In Acute Myeloid Leukemia, Jessica Dyanne Hess
Open Access Theses & Dissertations
Anticancer drug discovery is a time and resource-consuming process for which exceedingly reliable and efficient modern approaches are needed. Phenotypic drug screenings can generate highly potent and innovative drug candidates; however, deconvolution of the drugâ??s target often presents significant barriers to drug development. To overcome this hurdle, we have originally combined in vitro and in silico analyses to uncover the molecular mechanism(s) driving the anticancer activity of the uniquely structured small molecule drug candidate, Tpz-1. Our study revealed that Tpz-1 is a multitargeted agent which induces the programmed death of HL-60 acute myeloid leukemia cells primarily through disruption of microtubule …
In Vitro Investigation Of Tumor Selective Piperidones As Therapeutic Agents Against Leukemia Cancer Cells, Lisett Contreras
In Vitro Investigation Of Tumor Selective Piperidones As Therapeutic Agents Against Leukemia Cancer Cells, Lisett Contreras
Open Access Theses & Dissertations
Cancer is a continuous global health issue. It is the second leading cause of death behind heart disease. Disparities across the emergence of cancer and resulting fatalities raise the importance of researching the disease. Treatments are available for certain types of cancers. However, these are typically accompanied by residual problems including side effects and the possibility for relapse. Some treatments attack all cells, leading to unwarranted side effects that make the possibility of living a comfortable life nearly impossible. Other treatments are specific to certain genetic alterations, making them only useful for a small percentage of patients. Not one treatment …
The Protective Effects Of Ferrostatin-1 (Fer-1) In Response To Excitotoxicity In Mouse Hippocampal Slices, Mireya Nael Ramirez
The Protective Effects Of Ferrostatin-1 (Fer-1) In Response To Excitotoxicity In Mouse Hippocampal Slices, Mireya Nael Ramirez
Open Access Theses & Dissertations
The development of different neurological disorders has been associated with the accumulation of reactive oxygen species (ROS). Elevated ROS levels can disrupt the neuronal electrical activity. This phenomenon has been seen during epilepsy and neurodegenerative diseases like Parkinson's disease. Furthermore, the excess of ROS and development of such disorders have been linked to neuronal cell death partly due to excessive, non-physiological glutamate release. Ferroptosis is a recently defined iron-dependent cell death mechanism. Inducible by a small molecule called erastin, ferroptosis was first described in cancer cells. Erastin-induced ferroptosis differs from apoptosis, necrosis and autophagy, since it leads to different biochemical …
Assessment Of Carbon Nanoparticle Exposure On Murine Macrophage Function, Raquel M. Suro
Assessment Of Carbon Nanoparticle Exposure On Murine Macrophage Function, Raquel M. Suro
Open Access Theses & Dissertations
There is growing concern about the potential cytotoxicity of nanoparticles. Exposure to respirable ultrafine particles (2.5uM) can adversely affect human health and have been implicated with episodes of increased respiratory diseases such as asthma and allergies. Nanoparticles are of particular interest because of their ability to penetrate into the lung and potentially elicit health effects triggering immune responses. Nanoparticles are structures and devises with length scales in the 1 to 100-nanometer range. Black carbon (BC) nanoparticles have been observed to be products of combustion, especially flame combustion and multi-walled carbon nanotubes (MWCNT) have been shown to be found in both …