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Full-Text Articles in Life Sciences
Dna Methylation Patterns Of Specific L1 Loci On The Short Arm Of Chromosome 21, Sarah Ann Tincher
Dna Methylation Patterns Of Specific L1 Loci On The Short Arm Of Chromosome 21, Sarah Ann Tincher
Master's Theses
While 10-15% of the human genome is composed of heterochromatic DNA, these regions are not included in the completed genome sequence. The short arm of chromosome 21 (HC21p) serves as a model for understanding the structure and function of heterochromatin. LINE-1 (L1) retrotransposons are underrepresented in heterochromatin, including HC21p, and have not been extensively studied in these regions. However, there are disproportionately more full length L1s on HC21p than in euchromatic genomic regions. Decreased DNA methylation in the promoters of these L1s on HC21p may allow them to facilitate heterochromatin formation, which would be analogous to their proposed role in …
Functional Characterization Of A Novel Thioredoxin Domain-Containing Protein Of The Malaria Parasite Plasmodium, Rachel Kooistra
Functional Characterization Of A Novel Thioredoxin Domain-Containing Protein Of The Malaria Parasite Plasmodium, Rachel Kooistra
Master's Theses
A novel thioredoxin domain-containing protein of the malaria parasite Plasmodium was identified and found to be conserved among eukaryotes. This protein belongs to the phosducin-like family of proteins (PhLPs), and was therefore assigned the name PhLP1, since it is the first phosducin-like protein to be identified in Plasmodium. PhLPs have been found to have various roles in G-protein signaling, cell cycle progression, and protein folding. However, the biochemical mechanism by which PhLPs perform their function is unknown. Here is described the cloning and biochemical characterization of both PhLP1 and its human homolog TXNDC9. Both purified PhLP1 and TXNDC9 showed enzymatic …
Organization And Composition Of The Α21-Ii Region Of Human Chromosome 21, William Ziccardi
Organization And Composition Of The Α21-Ii Region Of Human Chromosome 21, William Ziccardi
Master's Theses
The purpose of this project was to develop a better map of the alpha 21-II region of human chromosome 21 in regards to size and primary sequence of the five alphoid clusters that comprise the region and to explore the evolutionary relationships that exist within and between these clusters. Several HC21 BACs were identified as containing strong sequence identities to alpha 21-II clones and were mapped to various alpha 21-II clusters. It was revealed that both monomeric and HOR alphoid clusters can be found in the alpha 21-II region. Phylogenetic analysis revealed separate evolutionary histories for the monomeric and HOR …
The Status Of Leptodactylus Validus As A Single Taxon And Its Relationship To Letptodactylus Pallidirostris, Kenneth Christopher Yanek
The Status Of Leptodactylus Validus As A Single Taxon And Its Relationship To Letptodactylus Pallidirostris, Kenneth Christopher Yanek
Master's Theses
Leptodactylus validus exhibits an unusual distribution inhabiting Trinidad, Tobago, and the Lesser Antilles, but not the mainland of South America. This distribution is inconsistent with other distribution patterns observed for these islands. Although slight variation in adult morphology has been observed among the island populations, call data suggest the presence of a single species. Calls of Leptodactylus pallidirostris from Venezuela suggested that this taxon might be conspecific with L. validus. Herein sequence data from the 12S and 16S mt rRNA genes were collected and analyzed in order to address: 1.) whether more than one species is represented within L. validus, …
The Non-Teratogenic Effects In Mice Progeny By Maternal Treatment With Amygdalin, Victoria Ann Rowe
The Non-Teratogenic Effects In Mice Progeny By Maternal Treatment With Amygdalin, Victoria Ann Rowe
Master's Theses
No abstract provided.