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Replication Of Gene-Gene Interactions In Large Alzheimer Disease Dataset, Kevin Boehme, Dr. John "Keoni" Kauwe
Replication Of Gene-Gene Interactions In Large Alzheimer Disease Dataset, Kevin Boehme, Dr. John "Keoni" Kauwe
Journal of Undergraduate Research
Alzheimer’s disease (AD) is a common and complex neurodegenerative disease. It is the most common cause of dementia and is characterized by the accumulation of amyloid plaques and neurofibrillary tangles. To date, many genetic loci have been found that modify AD risk, but collectively, they explain only a fraction of the heritability of the disease. It is hypothesized that rare variants with large effects as well as epistatic interactions account for much of the unexplained heritability in AD.