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Full-Text Articles in Life Sciences
Ab Blood Type And Its Genetic Relationship To Alzheimer’S Disease, Mark Wadsworth, John S. K. Kauwe
Ab Blood Type And Its Genetic Relationship To Alzheimer’S Disease, Mark Wadsworth, John S. K. Kauwe
Journal of Undergraduate Research
Alzheimer’s Disease (AD) is a debilitating disease that has increased the hardship of many lives. Many people above the age of 65 have been diagnosed with this genetically complex disease, which financially and emotionally burdens those diagnosed and their families. Earlier this year a study was released that found, using a dataset of individuals that have had strokes, that individuals with AB blood type are more at risk of developing cognitive impairment[1]. This study however was not looking at the genetics of AD. My objective in performing this study was to see if there is a genetic association between Alzheimer’s …
Presenilin E318g Variant And Alzheimer’S Disease Risk: The Cache Country Study, Ariel Hippen, John Kauwe
Presenilin E318g Variant And Alzheimer’S Disease Risk: The Cache Country Study, Ariel Hippen, John Kauwe
Journal of Undergraduate Research
Alzheimer’s disease is the leading cause of dementia in the elderly and the third most common cause of death in the United States. A vast number of genes regulate Alzheimer’s disease, including Presenilin 1 (PSEN1). It is possible that novel variants in the PSEN1 gene have an effect on Alzheimer’s disease status. A recent study suggested that one of these variants, PSEN1 E318G, significantly affects Alzheimer’s disease status in a large case-control dataset, particularly in connection with the APOEε4 allele [1].