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Genomic Correlates Of Relationship Qtl Involved In Fore- Versus Hind Limb Divergence In Mice, Mihaela Palicev, Gunter P. Wagner, James P. Noonan, Benedikt Hallgrimsson, James M. Cheverud

James Cheverud

Divergence of serially homologous elements of organisms is a common evolutionary pattern contributing to increased phenotypic complexity. Here, we study the genomic intervals affecting the variational independence of fore- and hind limb traits within an experimental mouse population. We use an advanced intercross of inbred mouse strains to map the loci associated with the degree of autonomy between fore- and hind limb long bone lengths (loci affecting the relationship between traits, relationship quantitative trait loci [rQTL]). These loci have been proposed to interact locally with the products of pleiotropic genes, thereby freeing the local trait from the variational constraint due …