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The Affective Disturbance Of Ethanol Withdrawal On C57bl/6j And C57bl/6nj Mice, Eric L. Levasseur
The Affective Disturbance Of Ethanol Withdrawal On C57bl/6j And C57bl/6nj Mice, Eric L. Levasseur
Honors College
The C57BL/6 (B6) mouse is the most commonly used inbred mouse strain in biomedical research. While the B6 mouse originated at The Jackson Laboratory, a number of separate breeding colonies are now maintained at various sites, resulting in genetic drift that has led to the emergence of both genotypic and phenotypic differences among these colonies. Two distinct substrains of B6 mice, C57BL/6J (B6J) and C57BL/6NJ (B6N), have been shown to differ on several addiction-related phenotypes, such as ethanol preference and locomotor responses to psychostimulants. Therefore, the aim of this study was to assess possible differences in depression- and anxiety-like behaviors …
Microglial Activation Immediately After Ethanol Withdrawal And 1 Week After Ethanol Withdrawal In Female C3h Mice, Sarah Holbrook
Microglial Activation Immediately After Ethanol Withdrawal And 1 Week After Ethanol Withdrawal In Female C3h Mice, Sarah Holbrook
Honors College
Alcohol abuse is the fourth leading cause of preventable death in the United States (National Institute on Alcohol Abuse and Alcoholism [NIAAA], 2016). Alcohol affects us on a molecular, biological, and even societal level. Liver damage, cancer, and drunk driving accidents are only a few adverse consequences of alcohol abuse. Studies have also shown that alcohol abuse can damage the brain, in part by activating the central nervous system’s immune system, leading to inflammation and demyelination. This damage may lead to alcohol-related psychiatric disorders, motor impairment, and cognitive disabilities. Studies have also shown that females tend to exhibit more damage …