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Association Between Prostate Cancer In Black Americans And An Allele Of The Padprp Pseudogene Locus On Chromosome 13, Helen Donis-Keller, Jennifer Doll, B Suarez
Association Between Prostate Cancer In Black Americans And An Allele Of The Padprp Pseudogene Locus On Chromosome 13, Helen Donis-Keller, Jennifer Doll, B Suarez
Helen Donis-Keller
Black American men have a higher incidence of cancer of the prostate (CAP), multiple myeloma, and lung cancer than do white American men (discussed by Lyn et al.1993a). The basis for these differences no doubt includes environmental influences, because American blacks have also been found to have a higher incidence of CAP than do African blacks. However, genetic factors may play a role as well. For example, Lyn et al. (1993a) reported an increase in the frequency of an allele of the poly(ADPribose)polymerase (PADPRP) pseudogene locus onchromosome 13 in black Americans with CAP, suggesting the presence of a disease-susceptibility locus. …
Genetic Analysis Of Prostatic Atypical Adenomatous Hyperplasia (Adenosis), Helen Donis-Keller, Jennifer Doll, Xiaopei Zhu, Jaime Furman, Zahid Kaleem, Carlos Torres, Peter Humphrey
Genetic Analysis Of Prostatic Atypical Adenomatous Hyperplasia (Adenosis), Helen Donis-Keller, Jennifer Doll, Xiaopei Zhu, Jaime Furman, Zahid Kaleem, Carlos Torres, Peter Humphrey
Helen Donis-Keller
Atypical adenomatous hyperplasia (AAH) of the prostate, a small glandular proliferation, is a putative precursor lesion to prostate cancer, in particular to the subset of well-differentiated carcinomas that arise in the transition zone, the same region where AAH lesions most often occur. Several morphological characteristics of AAH suggest a relationship to cancer; however, no definitive evidence has been reported. In this study, we analyzed DNA from 25 microdissected AAH lesions for allelic imbalance as compared to matched normal DNA, using one marker each from chromosome arms 1q, 6q, 7q, 10q, 13q, 16q, 17p, 17q, and 18q, and 19 markers from …