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The Binding Site Between The Adenoviral Protein E4 11k And The Cellular Protein Ddx6, O'Nekia Samuel
The Binding Site Between The Adenoviral Protein E4 11k And The Cellular Protein Ddx6, O'Nekia Samuel
Georgia College Student Research Events
Adenovirus is a nonenveloped virus that consists of an icosahedral capsid that contains double-stranded DNA. Viruses of this type can cause the common cold, conjunctivitis, and diarrhea. An important gene of adenoviruses is an early viral gene called E4 ORF3, which encodes the protein, E4 11k. This gene is responsible for changing the cellular environment, which aids in viral replication and prevents the host cell’s synthesis of proteins. E4 11k binds to Ddx6, a cellular protein located in P-bodies, and disrupts its localization. P-bodies are granules in the cytoplasm that contain mRNAs that have been repressed and proteins that are …