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The Role Of Foxd1 In Clear Cell Renal Cell Carcinoma, Kyle H. Bond
The Role Of Foxd1 In Clear Cell Renal Cell Carcinoma, Kyle H. Bond
Electronic Theses and Dissertations
Renal cell carcinoma (RCC) is the 8th most common cancer in the United States, with the clear cell variant (ccRCC) being the most prevalent. Over 14,000 people die every year to RCC, with rates continuing to increase with an aging general population. Patients suffering from metastatic RCC (mRCC) have extremely poor prognoses, with a 5-year survival of only 11.2%. Current treatment options include resection of primary lesions, tyrosine kinase inhibition (Sunitinib, Pazopanib), mTOR inhibition (Temsirolimus, Everolimus), and immune checkpoint inhibition (Nivolumab, Atezolizumab). Recent attention has been drawn to inhibition of transcription factors like HIF2α (Belzutifan). There is a need …
Characterizing Hematological And Reproductive Phenotypes In The Plk4+/– Mouse, Brayden Labute
Characterizing Hematological And Reproductive Phenotypes In The Plk4+/– Mouse, Brayden Labute
Electronic Theses and Dissertations
The polo-like kinases (Plks) are a family of serine/threonine kinases, of which there are five members. These protein kinases are involved in a multitude of processes associated with the cell cycle. These include centriole duplication, maturation of centrosomes, mitotic entry, and cytokinesis. Since the Plks are involved in such critical processes, dysregulation of these proteins are implicated in the development of a variety of malignancies. Higher and lower levels of Plk4 are both associated with tumourigenesis, therefore Plk4 can act as either an oncogene or tumour suppressor. While Plk4–/– mice are embryonic lethal, Plk4+/– mice are viable. Aged …