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Deciphering The Molecular Mechanism Through Which Rhus Coriaria Exerts Its Anti-Cancer Activity, Khawlah Najib Saeed Athamneh
Deciphering The Molecular Mechanism Through Which Rhus Coriaria Exerts Its Anti-Cancer Activity, Khawlah Najib Saeed Athamneh
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Cancer remains a major health problem around the globe. Among various types of treatments, plants have been shown to have great capacity in cancer treatment, one of which is Rhus coriaria. Commonly known as sumac, Rhus coriaria is a culinary herb that is known to possess different therapeutic values including anti-oxidant and anti-microbial activities.
In this Ph.D. project, we tested the effect of Rhus coriaria extract (RCE) on the migration, invasion, and metastasis of MDA-MB-231 human breast cancer cells. We showed that non-cytotoxic concentrations of RCE inhibited migration and invasion, blocked adhesion to fibronectin, and downregulated MMP-9. Additionally, we found …