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Sleeve Gastrectomy Leads To Weight Loss In The Magel2 Knockout Mouse, Deanna M. Arble, Joshua W. Pressler, Joyce Sorrell, Rachel Wevrick, Darleen A. Sandoval
Sleeve Gastrectomy Leads To Weight Loss In The Magel2 Knockout Mouse, Deanna M. Arble, Joshua W. Pressler, Joyce Sorrell, Rachel Wevrick, Darleen A. Sandoval
Biological Sciences Faculty Research and Publications
Background
Prader-Willi syndrome (PWS) is a genetic disorder characterized by hyperphagia, obesity, cardiopulmonary diseases, and increased mortality. Although successful weight loss improves health in PWS, few treatments cause sustained weight loss in obese patients let alone obese individuals with PWS.
Objectives
The present study uses the Magel2 knockout (KO) mouse, an animal model of PWS, to conduct a preclinical study on the efficacy of sleeve gastrectomy(SG) in PWS.
Setting
Academic research laboratory, United States.
Methods
We performed sham or SG surgeries in 24- to 28-week-old male Magel2 KO and wild-type littermate control mice (WT) who had been …