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Serotonin Modulates Oscillations Of The Membrane Potential In Isolated Spinal Neurons From Lampreys, I. V. Batueva, James Buchanan, N. P. Veselkin, E. I. Suderevskaya, E. A. Tsvetkov
Serotonin Modulates Oscillations Of The Membrane Potential In Isolated Spinal Neurons From Lampreys, I. V. Batueva, James Buchanan, N. P. Veselkin, E. I. Suderevskaya, E. A. Tsvetkov
Biological Sciences Faculty Research and Publications
Studies were performed on spinal neurons from lampreys isolated by an enzymatic/mechanical method using pronase. The effects of 100 µM serotonin (5-HT) on membrane potential oscillations induced by a variety of excitatory amino acids were studied. 5-HT was found to depolarize branched cells (presumptive motoneurons and interneurons) by 2–6 mV without inducing membrane potential oscillations. However, when oscillations were already present because of an excitatory amino acid, 5-HT changed the parameters of these oscillations, increasing the amplitudes of all types of oscillations, increasing the frequency of irregular oscillations, and increasing the duration of the depolarization plateaus accompanied by action potentials. …