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Asi1, A Gene Encoding A Novel Leucine Zipper Protein, Is Induced During Development Of The Macronucleus In Tetrahymena, Rupa A. Udani, Kathleen M. Karrer
Asi1, A Gene Encoding A Novel Leucine Zipper Protein, Is Induced During Development Of The Macronucleus In Tetrahymena, Rupa A. Udani, Kathleen M. Karrer
Biological Sciences Faculty Research and Publications
Sexual reproduction in the ciliate Tetrahymena follows a complex developmental program involving the sequential regulation of dozens of genes. Genes that are up-regulated during post-zygotic development in Tetrahymena were isolated by subtractive hybridization. Anlagen stage induced gene 1 (ASI1) encodes a 2.8 kb transcript that contains a single intron and is induced during macronuclear development. ASI1 is a single copy gene in both the micronucleus and the macronucleus. It encodes a 95 kDa conceptual protein with a leucine zipper near the amino terminus