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The Effects Of Serotonin On Functionally Diverse Isolated Lamprey Spinal Cord Neurons, I. V. Batueva, James T. Buchanan, N. P. Veselkin, E. I. Suderevskaya, E. A. Tsvetkov
The Effects Of Serotonin On Functionally Diverse Isolated Lamprey Spinal Cord Neurons, I. V. Batueva, James T. Buchanan, N. P. Veselkin, E. I. Suderevskaya, E. A. Tsvetkov
Biological Sciences Faculty Research and Publications
The experiments reported here showed that application of serotonin (5-hydroxytryptamine, 5-HT) (100 µ M) did not induce any significant current through the membranes of any of the spinal neurons studied (n = 62). At the same time, the membranes of most motoneurons and interneurons (15 of 18) underwent slight depolarization (2–6 mV) in the presence of 5-HT, which was not accompanied by any change in the input resistance of the cells. Depolarization to 10–20 mV occurred in some cells (3 of 18) of these functional groups, this being accompanied by 20–60% decreases in input resistance. The same concentration of 5-HT …