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Full-Text Articles in Life Sciences
Dual Requirement For Yeast Hnrnp Nab2p In Mrna Poly(A) Tail Length Control And Nuclear Export, Ronald E. Hector, Keith R. Nykamp, Sonia Dheur, James T. Anderson, Priscilla J. Non, Carl R. Urbinati, Scott M. Wilson, Lionel Minvielle‐Sebastia, Maurice S. Swanson
Dual Requirement For Yeast Hnrnp Nab2p In Mrna Poly(A) Tail Length Control And Nuclear Export, Ronald E. Hector, Keith R. Nykamp, Sonia Dheur, James T. Anderson, Priscilla J. Non, Carl R. Urbinati, Scott M. Wilson, Lionel Minvielle‐Sebastia, Maurice S. Swanson
Biological Sciences Faculty Research and Publications
Recent studies of mRNA export factors have provided additional evidence for a mechanistic link between mRNA 3′‐end formation and nuclear export. Here, we identify Nab2p as a nuclear poly(A)‐binding protein required for both poly(A) tail length control and nuclear export of mRNA. Loss of NAB2 expression leads to hyperadenylation and nuclear accumulation of poly(A)+ RNA but, in contrast to mRNA export mutants, these defects can be uncoupled in a nab2 mutant strain. Previous studies have implicated the cytoplasmic poly(A) tail‐binding protein Pab1p in poly(A) tail length control during polyadenylation. Although cells are viable in the absence of NAB2 expression …