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Mapping Genetic Variants Associated With Dynamic Protein Abundance In Haploid Yeast, Tanner Thuet-Davenport
Mapping Genetic Variants Associated With Dynamic Protein Abundance In Haploid Yeast, Tanner Thuet-Davenport
WWU Graduate School Collection
As organisms respond to changes in their environment genetic variation between individuals can directly affect organismal trait phenotypes by altering gene expression. Historically, studies have focused on the effect of genetic variation on mRNA synthesis (transcription) and decay rates. Relatively few studies have probed the relationship between DNA variants and protein-specific regulation of individual genes, despite the plethora of evidence that RNA levels are often poor proxies for protein levels. No study to date has mapped genetic variation associated with dynamic protein levels. In this study we investigated the location and identity of genetic variants acting on protein expression dynamics …