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A Molecular Traffic Jam: How Overexpression Of Pericentrin Restricts The Movement Of Ift20 Between The Golgi Apparatus And The Primary Cilium, Josh Mcnamara
Scholars Week
Virtually every cell in the human body has a small antenna projecting from its surface called a primary cilium (plural, cilia). Proteins must be constantly moved to and from cilia in order for cilia to continue their function. This movement is referred to as protein trafficking. IFT20 is a protein that is heavily involved in protein trafficking in and out of cilia. The trafficking patterns of IFT20 can be studied by making it visible under a fluorescent microscope. We are particularly interested in how IFT20 interacts with another protein around the cilium called Pericentrin and how their interaction affects IFT20 …