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Full-Text Articles in Life Sciences
Expression Of Insulin Responsive Genes In Insulin Resistant Conditions, And The Effect Of Selenium On Gene Expression, David L. Ruff
Expression Of Insulin Responsive Genes In Insulin Resistant Conditions, And The Effect Of Selenium On Gene Expression, David L. Ruff
Masters Theses
Chronically high blood glucose levels lead to many problems, such as insulin resistance, the hallmark of Type II diabetes. Increased flux through the hexosamine biosynthesis pathway is one mechanism by which high glucose as well as glucosamine has been shown to induce insulin resistance. This study tests the effects of glucosamine induced insulin resistance on insulin regulation of the metabolic genes glucose-6-phosphate dehydrogenase (G6PDH) and fatty acid synthase (FAS) as well as insulin responsive proteins tribbles homolog (TRIB3) and sterol regulatory element binding protein (SERBP-1c) 1c.
Selenium, a micronutrient has been shown to be an effective insulin mimetic in Type …
One Fish, Two Fish, Red Fish, Blue Fish: The Analysis Of The Specter Cell Cycle Mutant In Zebrafish, Tetiana Petrachkova
One Fish, Two Fish, Red Fish, Blue Fish: The Analysis Of The Specter Cell Cycle Mutant In Zebrafish, Tetiana Petrachkova
Masters Theses
Cell division is controlled by genes that regulate the cell cycle. Here we show that the zebrafish specter (spr) mutant is mutation in the cyclin B1 gene, a gene necessary for the G2 to M transition of the cell cycle.
The spr mutation mapped to the cyclin B1 gene. Sequencing showed a transition (C139→T) that caused a nonsense mutation in exon 2 of the cyclin B1 gene. In situ hybridization of cyclin B1 revealed that the mRNA is absent in the mutant embryo by gastrulation. We found that the earliest visible mutant phenotype was a darkening of the head caused …
A Gravity Investigation Of The Tobacco Root Batholith Southwest Montana, Stephen Charles Tatum
A Gravity Investigation Of The Tobacco Root Batholith Southwest Montana, Stephen Charles Tatum
Masters Theses
The objective of this research was to delineate and profile the Late Cretaceous Tobacco Root batholith in southwestern Montana through the application of the gravitational method. This survey was accomplished by obtaining 232 gravity measurements in four profiles across the batholith. After correcting for known variations in the gravity field, a Bouguer anomaly map of the batholith and surrounding host rocks was created. Four residual gravity profiles and map, created by subtracting the regional gravity from the Bouguer anomaly, reveal a maximum negative gravity anomaly in the center portion of the batholith which is parallel to the trend of the …