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Bystander Effects Due To Neutrons, And Low-Dose Hyper-Radiosensitivity To Gamma Rays In Human Cells Using Cytogenetics, Isheeta Seth
Bystander Effects Due To Neutrons, And Low-Dose Hyper-Radiosensitivity To Gamma Rays In Human Cells Using Cytogenetics, Isheeta Seth
Wayne State University Dissertations
Chapter 2:
Micronuclei have been used extensively in studies as an easily-evaluated indicator of DNA damage but little is known about their association with other types of damage such as nucleoplasmic bridges and nuclear buds. Radiation-induced clastogenic events were evaluated via the cytokinesis-block micronucleus assay in two normal human lymphoblastoid cell lines exposed to neutrons or gamma radiation. Micronuclei, nucleoplasmic bridges and nuclear buds were enumerated by recording the coincident presence of these endpoints within individual cells, and the associations among these three endpoints were evaluated for all treatment conditions. The common odds ratios for micronuclei and nucleoplasmic bridges were …
Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation, Marina Victoria Bakhmutsky
Cytogenetic Analysis Of Depleted Uranium Exposure And Age-Dependent Susceptibility To Ionizing Radiation, Marina Victoria Bakhmutsky
Wayne State University Dissertations
Chapters 2 and 3:
Depleted Uranium (DU) is a high-density heavy metal that has been used in munitions since the 1991 Gulf War. DU is weakly radioactive and chemically toxic and long term exposure may cause adverse health effects. This study evaluates genotoxic effects of DU exposure in Gulf War I Veterans as a function of uranium (U) body burden by measuring chromosome damage in peripheral blood lymphocytes with the cytokinesis blocked micronucleus assay (CBMN) and fluorescence in situ hybridization (FISH) whole chromosome painting. Study subjects are Gulf War I Veterans exposed to DU during friendly fire incidents in 1991 …