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Full-Text Articles in Life Sciences
The Mechanism Responsible For Mechanically Enhanced Cancer Cell Invasion, Alexander Nicholas Gasparski
The Mechanism Responsible For Mechanically Enhanced Cancer Cell Invasion, Alexander Nicholas Gasparski
Wayne State University Dissertations
Cell invasion is an important process utilized by cancer cells to progress through the metastatic cascade to form deadly secondary tumors. This process can be influenced by the wide array of biomechanical forces that cancer cells within and around a tumor face in their microenvironment. It is not completely clear how these forces, either alone or simultaneously combined with other forces, can impact the metastatic capacity of cancer cells. To address this, we have utilized an in vitro mechano-invasion assay to mimic a transient tugging force that exists within the tumor microenvironment caused by the remodeling of the extracellular matrix …
Identifying The Function Of The Calpain Small Subunit In The Mechanics Of Cell Migration, Bingqing Hao
Identifying The Function Of The Calpain Small Subunit In The Mechanics Of Cell Migration, Bingqing Hao
Wayne State University Dissertations
Cell migration plays a vital role in many physiological events including: morphogenesis, wound healing, and immune response. Dysfunctional cell migration results in multiple disease states including chronic inflammation, vascular disease, and tumor metastasis, to name a few. Progress in understanding the mechanism of cell migration had been slow until the turn of the century when rapid technological advances in microscopy and omics burst to the forefront. These advances led to the realization that physical factors (dimensions, fluid shear stress, hydrostatic pressure, compression stress, environmental stiffness, and topography) have profound effects on cell migration. This study of cell mechanics has expanded …