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Full-Text Articles in Life Sciences
Utilizing Immunopet To Measure Tumor Response To Treatment In Breast Cancer, Brooke Mcknight
Utilizing Immunopet To Measure Tumor Response To Treatment In Breast Cancer, Brooke Mcknight
Wayne State University Dissertations
With a broad spectrum of therapies available for treating breast cancer, the need for personalized medicine tailoring the cure according to phenotype is evident. Such an approach may be fully realized with the development of quantitative imaging technologies for disease detection, staging and diagnosis, without increasing patient burden. Immuno-positron emission tomography (PET) combines the targeted specificity of antibodies with the sensitivity of PET for whole body imaging by targeting molecular features amplified in lesions. ImmunoPET probes targeting different antigens and their utility to measure response to treatment were explored. 89Zr-trastuzumab was employed as a surrogate readout of Src inhibition after …
Role Of Ubiquitin E3 Ligase Breast Cancer Associated Gene 2 (Bca2) In Sumoylation, Fareea Khaliq
Role Of Ubiquitin E3 Ligase Breast Cancer Associated Gene 2 (Bca2) In Sumoylation, Fareea Khaliq
Honors College Theses
As the occurrence of breast cancer increases around the world, the need for new therapeutic medicine becomes more vital to sustain the population. In order to accomplish this, specific mechanisms need to be understood to gain a perspective on the overall process of breast cancer development. One mechanism that is being researched is SUMOylation. The SUMOylation reaction uses small ubiquitin-like modifier (SUMO) proteins, which act as a type of post-translational modification that is necessary in order to preserve protein homeostasis and regulate cellular processes including apoptosis, cell proliferation, and response to stress. The SUMOs attach to a target protein through …