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Articles 1 - 4 of 4
Full-Text Articles in Life Sciences
Utilizing Immunopet To Measure Tumor Response To Treatment In Breast Cancer, Brooke Mcknight
Utilizing Immunopet To Measure Tumor Response To Treatment In Breast Cancer, Brooke Mcknight
Wayne State University Dissertations
With a broad spectrum of therapies available for treating breast cancer, the need for personalized medicine tailoring the cure according to phenotype is evident. Such an approach may be fully realized with the development of quantitative imaging technologies for disease detection, staging and diagnosis, without increasing patient burden. Immuno-positron emission tomography (PET) combines the targeted specificity of antibodies with the sensitivity of PET for whole body imaging by targeting molecular features amplified in lesions. ImmunoPET probes targeting different antigens and their utility to measure response to treatment were explored. 89Zr-trastuzumab was employed as a surrogate readout of Src inhibition after …
Predicting The Structure And Selectivity Of Coiled-Coil Proteins, Mojtaba Jokar
Predicting The Structure And Selectivity Of Coiled-Coil Proteins, Mojtaba Jokar
Wayne State University Dissertations
A coiled-coil protein structure consists of two (in coiled-coil dimers) or more interacting α-helical strands that together form a left-handed supercoil structure. Many coiled-coil proteins are involved in significant biological functions such as the regulation of gene expression, known as transcription factors. Also coiled-coil structures entail unique mechanical properties critical to the function and integrity of various motor proteins, cytoskeletal filaments and extra-cellular matrix proteins. Engineering these transcription factors is also expected to create more efficient and practical solutions to treat neurodegenerative diseases such as Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), amyotrophic lateral sclerosis (ALS) and prion …
Abelson Tyrosine Kinase Links Axon Guidance Receptors To Cytoskeletal Dynamics Through Protein-Protein Interactions Mediated By Its C-Terminal Domain, Han Sian Joshua Cheong
Abelson Tyrosine Kinase Links Axon Guidance Receptors To Cytoskeletal Dynamics Through Protein-Protein Interactions Mediated By Its C-Terminal Domain, Han Sian Joshua Cheong
Wayne State University Dissertations
Abelson tyrosine kinase (Abl) is a key player in axon guidance, where it functions to link a multitude of axon guidance receptors to actin cytoskeletal dynamics. The C-terminal domain (CTD) of Abl is instrumental to Abl function, but its role is poorly explored due to a lack of conserved sequence elements. Here, we use a systematic approach to identify regions of the CTD important for Abl function, and define two regions (the first and third quarters, 1Q and 3Q) important for Abl function. We demonstrate that both these regions are likely intrinsically disordered, and function in scaffolding to recruit Abl …
Perturbation Of Energy Metabolism At The Center Of The Mechanism Of Action Of Valproate, Michael Ghassan Salsaa
Perturbation Of Energy Metabolism At The Center Of The Mechanism Of Action Of Valproate, Michael Ghassan Salsaa
Wayne State University Dissertations
Bipolar disorder (BD) is a common and debilitating psychiatric disorder. Valproic acid (VPA) is one of the major drugs used to treat BD patients. However, it is not universally effective and, in addition, causes severe side effects. Its mechanism of action is not known, which complicates efforts to develop more effective drugs. Studies have established that VPA perturbs metabolism, which is implicated in both the therapeutic mechanism of action of the drug as well as drug toxicity. However, the mechanism whereby VPA causes these perturbations is not understood. To address this knowledge gap, I investigated the acute and chronic effects …