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Mouse Ribonuclease Iii. Cdna Structure, Expression Analysis, And Chromosomal Location, Kristine R. Fortin, Rhonda H. Nicholson, Allen W. Nicholson
Mouse Ribonuclease Iii. Cdna Structure, Expression Analysis, And Chromosomal Location, Kristine R. Fortin, Rhonda H. Nicholson, Allen W. Nicholson
Wayne State University Associated BioMed Central Scholarship
Abstract
Background
Members of the ribonuclease III superfamily of double-stranded(ds)-RNA-specific endoribonucleases participate in diverse RNA maturation and decay pathways in eukaryotic and prokaryotic cells. A human RNase III orthologue has been implicated in ribosomal RNA maturation. To better understand the structure and mechanism of mammalian RNase III and its involvement in RNA metabolism we determined the cDNA structure, chromosomal location, and expression patterns of mouse RNase III.
Results
The predicted mouse RNase III polypeptide contains 1373 amino acids (~160 kDa). The polypeptide exhibits a single C-terminal dsRNA-binding motif (dsRBM), tandem catalytic domains, a proline-rich region (PRR) and an RS domain. …