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Role Of Secretory Leukocyte Protease Inhibitor In Urinary Tract Infection, Anne Rosen
Role Of Secretory Leukocyte Protease Inhibitor In Urinary Tract Infection, Anne Rosen
Arts & Sciences Electronic Theses and Dissertations
Urinary tract infections (UTIs) affect 150 million people per year worldwide and can be difficult to diagnose and treat leaving room for other biomarkers to be used to define an infection. Secretory leukocyte protease inhibitor (SLPI), an antimicrobial protein also with antiprotease and anti-inflammatory properties, may be involved in host response to UTI. Here we use an established UPEC-UTI model to infect female Slpi knockout and wild type mice to show SLPI plays a role in microbial ecology of the bladder. Bacterial abundance is altered in urinary tracts and is positively correlated with SLPI in urine of wild type mice. …