Life Sciences Commons^™

The Periaqueductal Grey In Opioid Tolerance And Chronic Pain, Akila Ram

All Graduate Theses and Dissertations, Spring 1920 to Summer 2023

Pain is the body’s natural warning system to indicate one is in an environment highly detrimental to survival. The body’s response to the sensation of pain is to immediately withdraw from this environment, ensuring continued survival. However, when pain lasts beyond the window in which it is useful, it no longer serves as a helpful warning system but instead degrades the quality of life. Chronic pain leads to patients seeking opioids to alleviate their condition and regain control of their lives. A severe negative side effect of the use of opioids to treat chronic pain is the development of tolerance …