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The Characteristic Structural Features Of The Blood Vessels Of The Lewis Lung Carcinoma (A Light Microscopic And Scanning Electron Microscopic Study), T. W. Grunt, A. Lametschwandtner, K. Karrer
The Characteristic Structural Features Of The Blood Vessels Of The Lewis Lung Carcinoma (A Light Microscopic And Scanning Electron Microscopic Study), T. W. Grunt, A. Lametschwandtner, K. Karrer
Scanning Electron Microscopy
Vascular corrosion casts of Lewis lung carcinomas (LLC) grown subcutaneously in C57BL/6-mice are correlated with histological sections and with tumor tissue prepared for scanning electron microscopy (SEM). By making low, medium and high pressure cast preparations we studied the influence of perfusion and injection pressure on the resulting cast sample.
Three types of vascular proliferations are distinguishable in LLC: 1) Small globular outgrowths on sinusoidal dilated tumor capillaries, caused by proliferation of their endothelial cells. 2) New sprouts on surrounding host vessels, invading the small, still avascular implant. 3) Superficially located, centrifugally running sprouts in peripheral regions of large tumors. …
The Angioarchitecture Of The Lewis Lung Carcinoma In Laboratory Mice (A Light Microscopic And Scanning Electron Microscopic Study), T. W. Grunt, A. Lametschwandtner, K. Karrer, O. Staindl
The Angioarchitecture Of The Lewis Lung Carcinoma In Laboratory Mice (A Light Microscopic And Scanning Electron Microscopic Study), T. W. Grunt, A. Lametschwandtner, K. Karrer, O. Staindl
Scanning Electron Microscopy
53 Lewis lung carcinomas implanted subcutaneously into C57BL/6-mice were examined. The animals were killed at various stages of tumor growth (TG) and prepared for histology and for scanning electron microscopy (critical-point-dried tissue; vascular corrosion casts). Prior to casting animals were rinsed using different perfusion pressures. Casting was done by manual injection of the resin, whereby different influx-rates were applied resulting in low, medium and high pressure preparations.
We discern 3 phases of tumor angiogenesis (TA) occurring during 4 stages of TG among which vasodilation establishes the first reaction of the host vascular system to a growing tumor implant. During this …