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Quantitative Vascular Casting Of The Post-Ischemic Hydronephrotic Kidney, Vincent H. Gattone Ii, Robert D. Sale
Quantitative Vascular Casting Of The Post-Ischemic Hydronephrotic Kidney, Vincent H. Gattone Ii, Robert D. Sale
Scanning Electron Microscopy
The renal microvasculature (afferent arteriole) and glomeruli were examined and quantitated by two methods in the post-ischemic hydronephrotic (PIH) kidney. The methods used were: 1) an in vivo examination and 2) controlled perfusion-fixation, quantitative vascular casting examined by scanning electron microscopy. The second method was also applied to the vasculature of the contralateral, functional kidney. The goals of the study were to: 1) validate the quantitative vascular casting method by comparing PIH renal microvascular data from the casting method with in vivo values and 2) determine the extent of microvascular dimensional difference of the PIH kidney from its contralateral functional …
Quantitative Renal Vascular Casting In Nephrology Research, Vincent H. Gattone Ii, Andrew P. Evan
Quantitative Renal Vascular Casting In Nephrology Research, Vincent H. Gattone Ii, Andrew P. Evan
Scanning Electron Microscopy
The present paper describes the use of a quantitative renal vascular casting method to study the changes associated with kidney disease. Several animal models of hypertension (spontaneously hypertensive rat, SHR, with its normotensive rat the Wistar Kyoto, WKY; Dahl salt sensitive DS - hypertensive, and salt resistant DR -normotensive) were examined at time points when the systemic blood pressure was rising (6 and 12 weeks of age) and following renal denervation (in SHR-WKY rats). The SHR appears to have a smaller caliber afferent arteriole at both 6 and 12 weeks of age. This difference is probably not entirely due to …