Life Sciences Commons^™

The Sumoylation Of The Non-Structural Protein 1 Of The Influenza A Virus Plays A Dual Role During Viral Infection, Jason Michael Chacon

Open Access Theses & Dissertations

The potential for a highly pathogenic influenza pandemic remains a concern for global health. The ability of the influenza virus to undergo antigenic shift and genetic drift give circulating strains of influenza the high probability of developing resistance to current antiviral therapies. Emerging strains of higher virulence, to which the infected person has not had any previous exposure to viral antigens, pose a greater threat of serious illness and death. Currently, there is no antiviral therapy that is effective against all strains of influenza, emphasizing the need to develop new strategies that target cellular systems required for viral replication to …

Effects Of The Cellular Sumoylation System On The Influenza Nuclear Export Protein (Nep), Karla Prieto

Open Access Theses & Dissertations

The high genetic compatibility between the 2009 H1N1 pandemic "swine flu" and the highly pathogenic H5N1 "bird flu" viruses indicates that the odds of a deadly bird flu strain mingling its genetic material with a human virus and becoming easily transmissible among humans are at an all-time high. This fact stresses the urgent need for new treatment and prevention methods to combat influenza. Our current anti-influenza weapons include vaccination and two type of antivirals that

target specific viral components (the so-called M2 ion channel inhibitors and the neuraminidase inhibitors). However, the high genetic variability of the virus enables it to …

Role Of Post-Translational Modifications In The Hiv Cofactor Activity Of Ledgf/P75, Denisse Adriana Gutierrez

Open Access Theses & Dissertations

see document.