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Characterization Of Gabaergic Horizontal Cells In The Mouse Retina, Zulema Uresti
Characterization Of Gabaergic Horizontal Cells In The Mouse Retina, Zulema Uresti
Open Access Theses & Dissertations
The inner nuclear layer of the mammalian retina contains the cell bodies of the amacrine, bipolar and horizontal neurons. About 90% of the amacrine neurons are glycinergic and GABAergic and marked by the expression of the vesicular inhibitory amino acid transporter, VIAAT. By contrast, the phenotype in horizontal inhibitory neurons vary among different mammals. In the primate retina, experimental evidence suggests the absence of VIAAT and hypothesizing that GABA could be released by efflux through the GABA transporters. On the other hand, in rodents, the horizontal cells express the VIAAT and carry out vesicle-dependent GABA release. Although the retina cells …
Sex Differences In The Mechanisms That Modulate The Neurochemical Effects Of Nicotine, Kevin Uribe
Sex Differences In The Mechanisms That Modulate The Neurochemical Effects Of Nicotine, Kevin Uribe
Open Access Theses & Dissertations
Prior behavioral studies in our laboratory revealed that overexpression of the stress peptide, corticotrophin-releasing factor (CRF), in the mesocorticolimbic reward pathway enhanced the reinforcing effects of nicotine. The latter effect was greater in female versus male rats, suggesting that females are uniquely susceptible to the effects of stress on nicotine reinforcement. The goal of this dissertation was to examine the neurochemical mechanisms by which overexpression of CRF in the nucleus accumbens (NAc), a terminal region of the mesocorticolimbic pathway, modulates the behavioral effects of nicotine. Specifically, we examined whether nicotine-induced dopamine levels are altered by CRF overexpression via excitatory (glutamate) …