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Full-Text Articles in Life Sciences
Region-Specific Modifications Of Synaptic Proteins In Response To Early-Life Adversity In The Rat Brain, Jameel Nasser Hamdan
Region-Specific Modifications Of Synaptic Proteins In Response To Early-Life Adversity In The Rat Brain, Jameel Nasser Hamdan
Open Access Theses & Dissertations
Drug addiction is a serious condition affecting approximately 19.7 million people in the United States alone (SAMHSA 2018). Exposure to stress and other adverse conditions has been shown to impact drug-taking behavior and making individuals more vulnerable to addiction. In those already suffering from addiction, abstaining from drug use often gives way to relapse after a stressful event (Lu, Shepard et al. 2003; Shaham, Erb et al. 2000). The experience of adversity during early-life can cause long-lasting changes in the brain, affecting development, behavior, learning and memory, and critical thinking processes, which may persist into adulthood (Aisa, Tordera et al. …
Influence Of Stress On Substance Use: Age-Associated Variability In Molecular And Behavioral Outcomes, Christina Elizabeth D'Arcy
Influence Of Stress On Substance Use: Age-Associated Variability In Molecular And Behavioral Outcomes, Christina Elizabeth D'Arcy
Open Access Theses & Dissertations
Stress introduces a number of neurological and neurohormonal changes in response to a number of stimuli, and can influence our relationship to rewarding experiences. As such, it holds the potential of promoting vulnerability to addiction to substances such as methamphetamine. While methamphetamine use and abuse has been steadily declining, the fact remains that it and closely related drugs are used in the treatment of conditions such as narcolepsy, weight loss, and attention deficit disorder. In an effort to develop better patient assessment metrics to aid the physician in deciding a course of treatment, we ask the following questions: Do chronic …