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Full-Text Articles in Life Sciences
Intracellular Hemin Is A Potent Inhibitor Of The Voltage-Gated Potassium Channel Kv10.1, Nirakar Sahoo, Kefan Yang, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann
Intracellular Hemin Is A Potent Inhibitor Of The Voltage-Gated Potassium Channel Kv10.1, Nirakar Sahoo, Kefan Yang, Alisa Bernert, Sandip M. Swain, Guido Gessner, Reinhard Kappl, Toni Kühl, Diana Imhof, Toshinori Hoshi, Roland Schönherr, Stefan H. Heinemann
Biology Faculty Publications and Presentations
Heme, an iron-protoporphyrin IX complex, is a cofactor bound to various hemoproteins and supports a broad range of functions, such as electron transfer, oxygen transport, signal transduction, and drug metabolism. In recent years, there has been a growing recognition of heme as a non-genomic modulator of ion channel functions. Here, we show that intracellular free heme and hemin modulate human ether à go-go (hEAG1, Kv10.1) voltage-gated potassium channels. Application of hemin to the intracellular side potently inhibits Kv10.1 channels with an IC50 of about 4 nM under ambient and 63 nM under reducing conditions in a weakly voltage-dependent manner, …
Effectiveness Of The Flipped Classroom Model In Anatomy And Physiology Laboratory Courses At A Hispanic Serving Institution, Gerardo Sanchez
Effectiveness Of The Flipped Classroom Model In Anatomy And Physiology Laboratory Courses At A Hispanic Serving Institution, Gerardo Sanchez
Theses and Dissertations
A flipped laboratory model involves significant preparation by the students on lab material prior to entry to the laboratory. This allows laboratory time to be focused on active learning through experiments. The aim of this study was to observe changes in student performance through the transition from a traditional laboratory format, to a flipped format. The data showed that for both Anatomy and Physiology (I and II) laboratories a more normal distribution of grades was observed once labs were flipped and lecture grade averages increased. Chi square and analysis of variance tests showed grade changes to a statistically significant degree, …
The Biological Flora Of Coastal Dunes And Wetlands. Sesuvium Portulacastrum (L.) L., Robert I. Lonard, Frank W. Judd
The Biological Flora Of Coastal Dunes And Wetlands. Sesuvium Portulacastrum (L.) L., Robert I. Lonard, Frank W. Judd
Biology Faculty Publications and Presentations
Sesuvium portulacastrum (L.) L. (sea purslane, cenicilla) is a pantropical, perennial, trailing herb (Aizoaceae) with pink-purple or occasionally white flowers that grows on coastal beaches of five continents and many islands. Herein we present a review of the biology of S. portulacastrum. It is an important pioneer species on sandy beaches in the subtropics and tropics, where its stoloniferous, mat-forming growth habit promotes embryonic dune formation in belts parallel to the shoreline. Colonies act as barriers to intercept and hold water and wind transported sand. Sesuvium portulacastrum's success as a colonizing species is related, in large part, to its …