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Full-Text Articles in Life Sciences
Characterization Of Bpa Sensitive Strains In C. Elegans, Giulianna I. Escobar
Characterization Of Bpa Sensitive Strains In C. Elegans, Giulianna I. Escobar
Honors Theses
Bisphenol A (BPA) has been present in our environment since 1891 when it was first synthesized by Aleksandr Dianin. BPA has since been a topic of interest due to the possibility of diseases associated in human consumption of the chemical. Interestingly, Caenorhabditiselegans, commonly known as C.eleganshave shown to be able to tolerate the chemical. Thisorganism is an advantageous model organism for research since they are simple organisms to study, cheap, produce a large brood size, and have a short life cycle. Previously a forward genetic screen was done to isolate 2000 healthy strains in order to determine which strains showed …
The Functionally Relevant Role Of Sdrna-19b And Sdrna-24 In Prostate Cancer, Addison A. Barchie
The Functionally Relevant Role Of Sdrna-19b And Sdrna-24 In Prostate Cancer, Addison A. Barchie
Honors Theses
In recent studies small nucleolar RNAs (snoRNA) have been shown to be processed into smaller microRNA-like fragments known as sno-derived RNA (sdRNA). We recently identified 9 snoRNAs that contribute to prostate malignancy using The Cancer Genome Atlas (TCGA) patient prostate tumor next-generation sequencing datasets. These snoRNA were found to be processed into sdRNAs, heavily misexpressed in prostate cancer cell types 8140 and 8550, and shown to function by binding Ago proteins in order to impact mRNA translation. SdRNA-19b and sdRNA-24 in particular stood out as having significant differential expression in prostate cancer vs. control tissue. Interestingly, the targets for sdRNA-19b …