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Poor Compliance With An Antibiotic Directive—A Call For Intensified Monitoring, Frederik Novak, Jens T. Hørlück, Jacob D. Redder, Paul Denton, Merete Storgaard
Poor Compliance With An Antibiotic Directive—A Call For Intensified Monitoring, Frederik Novak, Jens T. Hørlück, Jacob D. Redder, Paul Denton, Merete Storgaard
Biology Faculty Publications
Background
In April 2017, the Central Denmark Region Antibiotic Stewardship Committee issued a directive to reduce the general use of piperacillin-tazobactam and prescribe narrow-spectrum antibiotics for mild and moderate pneumonia. The directive was distributed to all regional hospital clinicians.
Methods
Electronic medical records were used to obtain de-identified details of all antibiotics administered (together with diagnosis codes) to all in-hospital patients (pre-directive and post-directive) in the nine regional hospitals. Average moving range statistical process control charts were used to analyze pre-directive and post-directive variation in antibiotic usage patterns.
Results
Upon the distribution of the directive, a period of decline of …