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Articles 1 - 17 of 17
Full-Text Articles in Life Sciences
Functional Morphology, Biomechanics, And Evolution Of Ruminant Mammals, Abby Vander Linden
Functional Morphology, Biomechanics, And Evolution Of Ruminant Mammals, Abby Vander Linden
Doctoral Dissertations
Ruminant mammals, including the families Bovidae, Cervidae, Tragulidae, Moschidae, Antilocapridae, and Giraffidae, display incredible past and present diversity in morphology, ecology, and behavior. They inhabit an impressive range of environments across North and South America, Europe, Asia, and Africa, and compel the fascination of naturalists and researchers alike with their charismatic social behavior and conspicuous cranial appendages. I explore the drivers and consequences of this spectacular diversity through a comparative morphological framework, biomechanical modeling approaches, and semi-parametric and likelihood-based methods for estimating state-dependent diversification rates across the ruminant phylogeny. Together, these investigations provide evidence for adaptation via correlated evolution of …
The Time Course And Neuroanatomy Of Rhinophore Regeneration In The Nudibranch Berghia Stephanieae, Ani Maroyan
The Time Course And Neuroanatomy Of Rhinophore Regeneration In The Nudibranch Berghia Stephanieae, Ani Maroyan
Masters Theses
Within five weeks, the nudibranch, Berghia stephanieae (Gastropoda, Mollusca) can regenerate a severed rhinophore, the main olfactory appendage, such that it is indistinguishable from a non-lesioned rhinophore. The rhinophore is a 2 mm long stalk with lateral sides covered in ridges and the distal third covered in fluorescent pigmentation. Its internal morphology is dominated by longitudinal musculature, overlaid by a complex neuronal plexus, which contains neurons that express various neuroactive substances including serotonin and small cardioactive peptide (SCP). Two large nerves originate in the rhinophore ganglion at the base of the rhinophore and run the length of the rhinophore. To …
Development Of A New Behavioral Assay For Juvenile Berghia Stephanieae, Kelly E. Fischer
Development Of A New Behavioral Assay For Juvenile Berghia Stephanieae, Kelly E. Fischer
Masters Theses
Developing robust behavioral assays to study olfactory-driven behaviors allows for greater insight into the neural mechanisms behind them. Oftentimes, olfactory behavioral assays require a two-choice design, consistent variables, and controlled stimulus application. This can be challenging when working with marine dwelling organisms such as nudibranchs. Extensive work shows the importance of olfaction in both pre-metamorphic larval development and adult stage nudibranchs (Gastropoda, Mollusca). However, there is little research investigating how olfaction plays a role in rapidly developing, post-metamorphic juvenile nudibranchs such as Berghia stephanieae. To study olfactory-associated behaviors in juvenile Berghia, a novel behavioral microfluidic chip was designed which …
Monitoring Mammals At Multiple Scales: Case Studies From Carnivore Communities, Kadambari Devarajan
Monitoring Mammals At Multiple Scales: Case Studies From Carnivore Communities, Kadambari Devarajan
Doctoral Dissertations
Carnivores are distributed widely and threatened by habitat loss, poaching, climate change, and disease. They are considered integral to ecosystem function through their direct and indirect interactions with species at different trophic levels. Given the importance of carnivores, it is of high conservation priority to understand the processes driving carnivore assemblages in different systems. It is thus essential to determine the abiotic and biotic drivers of carnivore community composition at different spatial scales and address the following questions: (i) What factors influence carnivore community composition and diversity? (ii) How do the factors influencing carnivore communities vary across spatial and temporal …
Diversity And Evolution Of Human Eccrine Sweat Gland Density, Andrew W. Best
Diversity And Evolution Of Human Eccrine Sweat Gland Density, Andrew W. Best
Doctoral Dissertations
Human eccrine density is highly derived. However, little is known about contemporary variation in this trait, what shapes it, and how it influences heat dissipation. This project explores 3 questions: 1) Is variation in functional eccrine density (FED) explained by childhood climate? 2) Is this variation patterned by geographic ancestry? 3) Is variation in FED associated with differences in heat dissipation capacity? We measured FED and sweat production in 6 body areas via pharmacological stimulation and impressions of sweating skin in 72 participants. Childhood climate variables were taken from the WorldClim database and geographic ancestry was estimated with 23andMe tests. …
Mechanisms Of Mitotic Checkpoint Silencing By The Disordered Kinetochore Protein Spc105, Margaux Audett
Mechanisms Of Mitotic Checkpoint Silencing By The Disordered Kinetochore Protein Spc105, Margaux Audett
Doctoral Dissertations
The kinetochore protein Spc105R (DmSpc105R) is a large intrinsically disordered protein (IDP) that recruits spindle assembly checkpoint (SAC) proteins and is required for SAC signaling in a conserved manner. Chromosome biorientation satisfies the SAC and while it has been proposed that SAC satisfaction may require the establishment of stable kinetochore-MT (KT-MT) attachments and tension generation, the question of whether tension directly regulates SAC signaling is unresolved and controversial. Here we present data in support of Spc105R as a tension-sensing IDP that directly regulates checkpoint protein localization and signaling independent of the establishment of stable KT-MT attachments. The N-terminus of DmSpc105R …
Factors Influencing Primate Hair Microbiome Diversity, Catherine Kitrinos
Factors Influencing Primate Hair Microbiome Diversity, Catherine Kitrinos
Masters Theses
Primate hair is both a substrate upon which essential social interactions occur and an important host-pathogen interface. As commensal microbes provide important immune functions for their hosts, understanding the microbial diversity in primate hair could provide insight into primate immunity and disease transmission. While studies of human hair and skin microbiomes show differences in microbial communities across body regions, little is known about the nonhuman primate hair microbiome. In this study, we collected hair samples (n=159) from 8 body regions across 12 nonhuman primate species housed at 3 US institutions to examine 1) the diversity and composition of the primate …
Dynamic Evolution In The Leucine-Rich Repeat Receptor-Like Kinase (Lrr-Rlk) Family Of Receptors, Jarrett Man
Dynamic Evolution In The Leucine-Rich Repeat Receptor-Like Kinase (Lrr-Rlk) Family Of Receptors, Jarrett Man
Doctoral Dissertations
Cells in multicellular organisms must gauge their environmental conditions, including neighboring cells, during development. In plants, the Leucine-Rich Repeat Receptor-like Kinases (LRR-RLKs) encode a family of membrane-bound receptors that transduce such cell-to-cell signals and are required for many aspects of plant development. Very little is known about the function of most of these genes, and the evolutionary history of the family is difficult to infer because of its size and complexity. Several factors contribute to this difficulty, including genetic redundancy, challenging bioinformatic detection, exceptionally large family size, and high copy number variation among species. In this dissertation, I characterize some …
Genomics And Transcriptomics Yields A System-Level View Of The Biology Of The Pathogen Naegleria Fowleri, Emily K. Herman, Alex Greninger, Mark Van Der Giezen, Michael L. Ginger, Immaculada Ramirez-Macias, Haylea C. Miller, Matthew J. Morgan, Anastasios D. Tsaousis, Katrina Velle, Romana Vargová
Genomics And Transcriptomics Yields A System-Level View Of The Biology Of The Pathogen Naegleria Fowleri, Emily K. Herman, Alex Greninger, Mark Van Der Giezen, Michael L. Ginger, Immaculada Ramirez-Macias, Haylea C. Miller, Matthew J. Morgan, Anastasios D. Tsaousis, Katrina Velle, Romana Vargová
Biology Department Faculty Publication Series
The opportunistic pathogen Naegleria fowleri establishes infection in the human brain, killing almost invariably within 2 weeks. The amoeba performs piece-meal ingestion, or trogocytosis, of brain material causing direct tissue damage and massive inflammation. The cellular basis distinguishing N. fowleri from other Naegleria species, which are all non-pathogenic, is not known. Yet, with the geographic range of N. fowleri advancing, potentially due to climate change, understanding how this pathogen invades and kills is both important and timely. Results Here, we report an -omics approach to understanding N. fowleri biology and infection at the system level. We sequenced two new strains …
Hp1Α Is A Chromatin Crosslinker That Controls Nuclear And Mitotic Chromosome Mechanics, Amy R. Strom, Ronald J. Biggs, Edward J. Banigan, Xiaoto Wang, Katherine Chiu, Cameron Herman, Jimena Collado, Feng Yue, Joan C. Ritland Politz, Leah J. Tait
Hp1Α Is A Chromatin Crosslinker That Controls Nuclear And Mitotic Chromosome Mechanics, Amy R. Strom, Ronald J. Biggs, Edward J. Banigan, Xiaoto Wang, Katherine Chiu, Cameron Herman, Jimena Collado, Feng Yue, Joan C. Ritland Politz, Leah J. Tait
Biology Department Faculty Publication Series
Chromatin, which consists of DNA and associated proteins, contains genetic information and is a mechanical component of the nucleus. Heterochromatic histone methylation controls nucleus and chromosome stiffness, but the contribution of heterochromatin protein HP1 alpha (CBX5) is unknown. We used a novel HP1 alpha auxin-inducible degron human cell line to rapidly degrade HP1 alpha. Degradation did not alter transcription, local chromatin compaction, or histone methylation, but did decrease chromatin stiffness. Single-nucleus micromanipulation reveals that HP1 alpha is essential to chromatin-based mechanics and maintains nuclear morphology, separate from histone methylation. Further experiments with dimerization-deficient HP1 alpha(I)(165E) indicate that chromatin crosslinking via …
Membrane-Partitioned Cell Wall Synthesis In Mycobacteria, Alam García-Heredia, Takehiro Kado, Caralyn E. Sein, Julia Puffal, Sarah H. Osman, Julius Judd, Todd A. Gray, Yasu S. Morita, M. Sloan Siegrist
Membrane-Partitioned Cell Wall Synthesis In Mycobacteria, Alam García-Heredia, Takehiro Kado, Caralyn E. Sein, Julia Puffal, Sarah H. Osman, Julius Judd, Todd A. Gray, Yasu S. Morita, M. Sloan Siegrist
Microbiology Department Faculty Publication Series
Many antibiotics target the assembly of cell wall peptidoglycan, an essential, heteropolymeric mesh that encases most bacteria. In rod-shaped bacteria, cell wall elongation is spatially precise yet relies on limited pools of lipid-linked precursors that generate and are attracted to membrane disorder. By tracking enzymes, substrates, and products of peptidoglycan biosynthesis in Mycobacterium smegmatis, we show that precursors are made in plasma membrane domains that are laterally and biochemically distinct from sites of cell wall assembly. Membrane partitioning likely contributes to robust, orderly peptidoglycan synthesis, suggesting that these domains help template peptidoglycan synthesis. The cell wall-organizing protein DivIVA and the …
Neural Representation Of Abstract Task Structure During Generalization, Avinash R. Vaidya, Henry M. Jones, Johanny Castillo, David Badre
Neural Representation Of Abstract Task Structure During Generalization, Avinash R. Vaidya, Henry M. Jones, Johanny Castillo, David Badre
Psychological and Brain Sciences Faculty Publication Series
Cognitive models in psychology and neuroscience widely assume that the human brain maintains an abstract representation of tasks. This assumption is fundamental to theories explaining how we learn quickly, think creatively, and act flexibly. However, neural evidence for a verifiably generative abstract task representation has been lacking. Here, we report an experimental paradigm that requires forming such a representation to act adaptively in novel conditions without feedback. Using functional magnetic resonance imaging, we observed that abstract task structure was represented within left mid-lateral prefrontal cortex, bilateral precuneus, and inferior parietal cortex. These results provide support for the neural instantiation of …
Spatio-Temporal Associations Between Deforestation And Malaria Incidence In Lao Pdr, Francois Rerolle, Emily Dantzer, Andrew A. Lover, John M. Marshall, Bouasy Hongvanthong, Hugh J. W. Sturrock, Adam Bennett
Spatio-Temporal Associations Between Deforestation And Malaria Incidence In Lao Pdr, Francois Rerolle, Emily Dantzer, Andrew A. Lover, John M. Marshall, Bouasy Hongvanthong, Hugh J. W. Sturrock, Adam Bennett
Biostatistics and Epidemiology Faculty Publications Series
As countries in the Greater Mekong Sub-region (GMS) increasingly focus their malaria control and elimination efforts on reducing forest-related transmission, greater understanding of the relationship between deforestation and malaria incidence will be essential for programs to assess and meet their 2030 elimination goals. Leveraging village-level health facility surveillance data and forest cover data in a spatio-temporal modeling framework, we found evidence that deforestation is associated with short-term increases, but long-term decreases confirmed malaria case incidence in Lao People's Democratic Republic (Lao PDR). We identified strong associations with deforestation measured within 30 km of villages but not with deforestation in the …
Extreme Morphology, Functional Trade-Offs, And Evolutionary Dynamics In A Clade Of Open-Ocean Fishes (Perciformes: Bramidae), Michelle C. Gilbert, Andrew J. Conith, Catherine S. Lerose, Joshua K. Moyer, Steve H. Huskey, R. Craig Albertson
Extreme Morphology, Functional Trade-Offs, And Evolutionary Dynamics In A Clade Of Open-Ocean Fishes (Perciformes: Bramidae), Michelle C. Gilbert, Andrew J. Conith, Catherine S. Lerose, Joshua K. Moyer, Steve H. Huskey, R. Craig Albertson
Biology Department Faculty Publication Series
Synopsis When novel or extreme morphologies arise, they are oft met with the burden of functional trade-offs in other aspects of anatomy, which may limit phenotypic diversification and make particular adaptive peaks inaccessible. Bramids (Perciformes: Bramidae) comprise a small family of 20 extant species of fishes, which are distributed throughout pelagic waters worldwide. Within the Bramidae, the fanfishes (Pteraclis and Pterycombus) differ morphologically from the generally stout, laterally compressed species that typify the family. Instead, Pteraclis and Pterycombus exhibit extreme anterior positioning of the dorsal fin onto the craniofacial skeleton. Consequently, they possess fin and skull anatomies that are radically …
Heterogeneous Contributions Of Change In Population Distribution Of Body Mass Index To Change In Obesity And Underweight, Ncd Risk Factor Collaboration
Heterogeneous Contributions Of Change In Population Distribution Of Body Mass Index To Change In Obesity And Underweight, Ncd Risk Factor Collaboration
Environmental Health Sciences Faculty Publication Series
From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape …
Deficient Spermiogenesis In Mice Lacking Rlim, Feng Wang, Maria Gracia Gervasi, Ana Bošković, Fengyun Sun, Vera D. Rinaldi, Mary C. Wallingford, Darya A. Tourzani, Jesse Mager, Lihua Julie Zhu, Oliver J. Rando
Deficient Spermiogenesis In Mice Lacking Rlim, Feng Wang, Maria Gracia Gervasi, Ana Bošković, Fengyun Sun, Vera D. Rinaldi, Mary C. Wallingford, Darya A. Tourzani, Jesse Mager, Lihua Julie Zhu, Oliver J. Rando
Veterinary & Animal Sciences Department Faculty Publication Series
The X-linked gene Rlim plays major roles in female mouse development and reproduction, where it is crucial for the maintenance of imprinted X chromosome inactivation in extraembryonic tissues of embryos. However, while females carrying a systemic Rlim knockout (KO) die around implantation, male Rlim KO mice appear healthy and are fertile. Here, we report an important role for Rlim in testis where it is highly expressed in post-meiotic round spermatids as well as in Sertoli cells. Systemic deletion of the Rlim gene results in lower numbers of mature sperm that contains excess cytoplasm, leading to decreased sperm motility and in …
Mpdb 2.0: A Large Scale And Integrated Medicinal Plant Database Of Bangladesh, Nazmul Hussain, Rony Chanda, Ruhshan Ahmed Abir, Mohsina Akter Mou, Md Kamrul Hasan, M Arif Ashraf
Mpdb 2.0: A Large Scale And Integrated Medicinal Plant Database Of Bangladesh, Nazmul Hussain, Rony Chanda, Ruhshan Ahmed Abir, Mohsina Akter Mou, Md Kamrul Hasan, M Arif Ashraf
Biology Department Faculty Publication Series
ObjectiveMPDB 2.0 is built to be the continuation of MPDB 1.0, to serve as a more comprehensive data repertoire for Bangladeshi medicinal plants, and to provide a user-friendly interface for researchers, health practitioners, drug developers, and students who wish to study the various medicinal & nutritive plants scattered around Bangladesh and the underlying phytochemicals contributing to their efficacy in Bangladeshi folk medicine.ResultsMPDB 2.0 database (https://www.medicinalplantbd.com/) comprises a collection of more than five hundred Bangladeshi medicinal plants, alongside a record of their corresponding scientific, family, and local names together with their utilized parts, information regarding ailments, active compounds, and PubMed ID …