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Discovery Of Sex-Specific Regions In A Salamander Genome, Nataliya Y. Timoshevskaya, Melissa C. Keinath, Jeramiah J. Smith
Discovery Of Sex-Specific Regions In A Salamander Genome, Nataliya Y. Timoshevskaya, Melissa C. Keinath, Jeramiah J. Smith
Commonwealth Computational Summit
Biological Aspects:
Salamander (Ambystoma mexicanum) has a gigantic genome: ~32,000,000,000 bases (10X of size of human genome)
Sex is determined by a pair of morphologically identical chromosomes:
- ZZ in male
- ZW in female
Object:
- Find (if there are any) genomic differences between chromosomes W and Z
Workflow:
- Sequencing and de novo assembly of the reference salamander genome
- Alignment of short sequences from male and female genomes to the reference
- Coverage analysis