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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Development And Application Of A Gis-Based Long Island Sound Eelgrass Habitat Suitability Index Model, Jamie M.P. Vaudrey, Justin Eddings, Christopher Pickerell, Lorne Brousseau, Charles Yarish
Development And Application Of A Gis-Based Long Island Sound Eelgrass Habitat Suitability Index Model, Jamie M.P. Vaudrey, Justin Eddings, Christopher Pickerell, Lorne Brousseau, Charles Yarish
Department of Marine Sciences
The primary objectives of the Eelgrass Habitat Suitability Index Model (EHSI Model) are to assist in the evaluation of sites being considered for eelgrass restoration efforts in the Long Island Sound (LIS) area and to identify areas where water quality issues reduce or eliminate the potential for natural eelgrass colonization. To achieve this goal, geospatial processing of data available from the Long Island Sound area was conducted using ArcGIS v10.0 including the 3D Analyst and Spatial Analyst extensions. The result is a series of maps presented in this report and a GIS-based model available for users to interact with the …
Pharmacological Inhibition Of Histone Methyltransferase G9a Affects Expression Of Citron Kinase Target Genes In Neural Stem Cells, Nicholas Heliotis
Pharmacological Inhibition Of Histone Methyltransferase G9a Affects Expression Of Citron Kinase Target Genes In Neural Stem Cells, Nicholas Heliotis
Honors Scholar Theses
Regulated repression of gene expression by post-translational modification of histones is required for normal development. The histone methyltransferase G9a is essential for embryonic development, and we have shown that phosphorylation of G9a by the CitK, a gene required for normal CNS development, gates gene repression and dimethylation of histone H3 at lysine 9 (H3K9me2) in neural progenitors. CitK and G9a co-localize to promoter regions of genes up-regulated in CitK null cells. CitK mutant progenitors lack H3K9me2 at promoter regions of up-regulated genes, and re-expression of CitK restores both repression of gene expression and H3K9me2 occupancy. In this thesis we examine …
The Effects Of Aging And Injury On The Murine Ependymal Barrier And Subventricular Zone, John Jeffrey Peters
The Effects Of Aging And Injury On The Murine Ependymal Barrier And Subventricular Zone, John Jeffrey Peters
University Scholar Projects
Previous research has shown that numerous age-related changes occur in the subventricular zone (SVZ) and diminish the neurogenic output of the region. Here, various agerelated changes in the structure of the lateral ventricle, the ependymal barrier, and the SVZ were examined. It was found that the walls of the lateral ventricles move together, adhere, and eventually fuse. This results in a degradation of the SVZ. Other changes associated with aging were found, including ependymal cell stretching, heightened, ependymal repair, changes in CSF flow velocity and dynamics, and altered ependymal cell polarity. These changes may be related to the process of …
In Vitro Characterization Of Avian Influenza Virus Isolates With A Truncated Ns1 Gene Segment, Aaron Dick
In Vitro Characterization Of Avian Influenza Virus Isolates With A Truncated Ns1 Gene Segment, Aaron Dick
Honors Scholar Theses
Avian Influenza Virus represents a significant threat to the world poultry population, and is a potential threat to humans due to the possibility of cross-species AIV infection. Our approach is to characterize a number of avian virus populations with respect to their content of biologically active particles that include hemagglutinating particles (HAP), plaque forming particles (PFP), interferon inducing particles (IFP), interferon induction-suppressing particles (ISP), defective-interfering particles (DIP), cell-killing particles (CKP) and non-infectious cell killing particles (niCKP) using unique in vitro assays developed for avian influenza virus in the Marcus-Sekellick Laboratory. Specifically, we will use a strain of Avian influenza virus, …
The Effects Of Aging And Injury On The Murine Ependymal Barrier And Subventricular Zone, John J. Peters
The Effects Of Aging And Injury On The Murine Ependymal Barrier And Subventricular Zone, John J. Peters
Honors Scholar Theses
Previous research has shown that numerous age-related changes occur in the subventricular zone (SVZ) and diminish the neurogenic output of the region. Here, various age-related changes in the structure of the lateral ventricle, the ependymal barrier, and the SVZ were examined. It was found that the walls of the lateral ventricles move together, adhere, and eventually fuse. This results in a degradation of the SVZ. Other changes associated with aging were found, including ependymal cell stretching, heightened, ependymal repair, changes in CSF flow velocity and dynamics, and altered ependymal cell polarity. These changes may be related to the process of …
Chemical And Biological Triggers For The Improved Intercalation And Release Of Glucose Oxidase (Go) In The Galleries Of Α-Zirconium Phosphate Nanolayers For A Noninvasive Oral Alternative To Insulin Drug Therapies, Momina Kamal Afrede
Honors Scholar Theses
Noninvasive treatment alternatives for diseases from diabetes to hypercholerestemia are at the cutting edge of research. Although many noninvasive drug delivery routes, including oral nasal, buccal, dermal, and pulmonary have been investigated no one route has been fully approved for patient use by the Food and Drug Administration (FDA) standards as an alternative to current needle dependent subcutaneous insulin delivery. 10 12 This thesis focuses on two novel oral protein drug delivery systems α-Zr(IV) phosphate (α-ZrP)-protein-Divalent Metal Ion and α-Zr(IV) phosphate (α-ZrP)-protein- cationized Bovine Serum Albumin BSA. Glucose oxidase (GO) serves as a model protein in this thesis for noninvasive …