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The Roles Of Human Cytomegalovirus Us27 Gene Product During Virus Infection, Carolyn C. Tu
The Roles Of Human Cytomegalovirus Us27 Gene Product During Virus Infection, Carolyn C. Tu
Master's Theses
Human cytomegalovirus (HCMV) is a widespread pathogen that causes lifelong latent infection. Successful persistence of HCMV in healthy individuals involves extensive manipulation of host cellular functions and immune responses. HCMV encodes four genes for putative G protein-coupled receptors (GPCRs): US27, US28, UL33, and UL78. The US28 gene product is a functional chemokine receptor that exhibits a variety of signaling outcomes. In contrast, the US27 gene product is an orphan with no known chemokine ligands. We have found that US27 triggers several biological effects: increased cellular proliferation, changes in gene expression, and enhanced signaling of cellular chemokine receptor CXCR4. Enhanced cell …