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The Affective Disturbance Of Ethanol Withdrawal On C57bl/6j And C57bl/6nj Mice, Eric L. Levasseur
The Affective Disturbance Of Ethanol Withdrawal On C57bl/6j And C57bl/6nj Mice, Eric L. Levasseur
Honors College
The C57BL/6 (B6) mouse is the most commonly used inbred mouse strain in biomedical research. While the B6 mouse originated at The Jackson Laboratory, a number of separate breeding colonies are now maintained at various sites, resulting in genetic drift that has led to the emergence of both genotypic and phenotypic differences among these colonies. Two distinct substrains of B6 mice, C57BL/6J (B6J) and C57BL/6NJ (B6N), have been shown to differ on several addiction-related phenotypes, such as ethanol preference and locomotor responses to psychostimulants. Therefore, the aim of this study was to assess possible differences in depression- and anxiety-like behaviors …