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The Effect Of Sex On Ischemia - Reperfusion Induced Arrhythmias And The Role Of Atp - Dependent Potassium Channel Blockage, Ersöz Gonca, Eylem Suveren Ti̇ryaki̇, Ömer Bozdoğan
The Effect Of Sex On Ischemia - Reperfusion Induced Arrhythmias And The Role Of Atp - Dependent Potassium Channel Blockage, Ersöz Gonca, Eylem Suveren Ti̇ryaki̇, Ömer Bozdoğan
Turkish Journal of Biology
The presence of more ATP-dependent potassium channels in females has been thought to play an important role in protection against myocardial ischemia. In this study, we investigated whether there is a difference in the severity of ischemia and reperfusion induced arrhythmias due to sex and, if there is, what the role of ATP-dependent potassium channel in this difference is. The left anterior descending coronary artery in rats was ligated and arrhythmias were recorded in ECG during 6 min. of ischemia and reperfusion. The duration of arrhythmias was shorter in females than in corresponding males. Glibenclamide was effective in decreasing the …