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Alternative Promoter Use Governs The Expression Of Iglon Cell Adhesion Molecules In Histogenetic Fields Of The Embryonic Mouse Brain, T. Jagomäe, K. Singh, M.-A. Philips, M. Jayaram, K. Seppa, T. Tekko, Scott F. Gilbert, E. Vasar, K. Lilleväli
Alternative Promoter Use Governs The Expression Of Iglon Cell Adhesion Molecules In Histogenetic Fields Of The Embryonic Mouse Brain, T. Jagomäe, K. Singh, M.-A. Philips, M. Jayaram, K. Seppa, T. Tekko, Scott F. Gilbert, E. Vasar, K. Lilleväli
Biology Faculty Works
The members of the IgLON superfamily of cell adhesion molecules facilitate fundamental cellular communication during brain development, maintain functional brain circuitry, and are associated with several neuropsychiatric disorders such as depression, autism, schizophrenia, and intellectual disabilities. Usage of alternative promoter-specific 1a and 1b mRNA isoforms in Lsamp, Opcml, Ntm, and the single promoter of Negr1 in the mouse and human brain has been previously described. To determine the precise spatiotemporal expression dynamics of Lsamp, Opcml, Ntm isoforms, and Negr1, in the developing brain, we generated isoform-specific RNA probes and carried out in situ hybridization in the developing (embryonic, E10.5, E11.5, …
The Combined Impact Of Iglon Family Proteins Lsamp And Neurotrimin On Developing Neurons And Behavioral Profiles In Mouse, K. Singh, K. Lilleväli, Scott F. Gilbert, A. Bregin, J. Narvik, M. Jayaram, M. Rahi, J. Innos, A. Kaasik, E. Vasar, M.-A. Philips
The Combined Impact Of Iglon Family Proteins Lsamp And Neurotrimin On Developing Neurons And Behavioral Profiles In Mouse, K. Singh, K. Lilleväli, Scott F. Gilbert, A. Bregin, J. Narvik, M. Jayaram, M. Rahi, J. Innos, A. Kaasik, E. Vasar, M.-A. Philips
Biology Faculty Works
Cell surface neural adhesion proteins are critical components in the complex orchestration of cell proliferation, apoptosis, and neuritogenesis essential for proper brain construction and behavior. We focused on the impact of two plasticity-associated IgLON family neural adhesion molecules, Neurotrimin (Ntm) and Limbic system associated membrane protein (Lsamp), on mouse behavior and its underlying neural development. Phenotyping neurons derived from the hippocampi of Lsamp−/−, Ntm−/− and Lsamp−/−Ntm−/− mice was performed in parallel with behavioral testing. While the anatomy of mutant brains revealed no gross changes, the Ntm−/− hippocampal neurons exhibited premature sprouting of neurites and manifested accelerated neurite elongation and branching. …