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Articles 1 - 7 of 7
Full-Text Articles in Life Sciences
Parentage Influence On Gene Expression Under Acidification Revealed Through Single-Embryo Sequencing, C. W. Fung, K. Y. Chau, D. C. S. Tong, C. Knox, S. S. T. Tam, S. Y. Tan, D. S. C. Loi, Z. Leung, Y. Xu, Y. Lan, P.-Y. Qian, Kit Yu Karen Chan, A. R. Wu
Parentage Influence On Gene Expression Under Acidification Revealed Through Single-Embryo Sequencing, C. W. Fung, K. Y. Chau, D. C. S. Tong, C. Knox, S. S. T. Tam, S. Y. Tan, D. S. C. Loi, Z. Leung, Y. Xu, Y. Lan, P.-Y. Qian, Kit Yu Karen Chan, A. R. Wu
Biology Faculty Works
The dissolution of anthropogenic carbon dioxide (CO2) in seawater has altered its carbonate chemistry in the process of ocean acidification (OA). OA affects the viability of marine species. In particular, calcifying organisms and their early planktonic larval stages are considered vulnerable. These organisms often utilize energy reserves for metabolism rather than growth and calcification as supported by bulk RNA-sequencing (RNA-seq) experiments. Yet, transcriptomic profiling of a bulk sample reflects the average gene expression of the population, neglecting the variations between individuals, which forms the basis for natural selection. Here, we used single-embryo RNA-seq on larval sea urchin Heliocidaris crassispina, which …
Early Chromosome Condensation By Xist Builds A-Repeat Rna Density That Facilitates Gene Silencing, M. Valledor, M. Byron, B. Dumas, Dawn M. Carone, L. L. Hall, J. B. Lawrence
Early Chromosome Condensation By Xist Builds A-Repeat Rna Density That Facilitates Gene Silencing, M. Valledor, M. Byron, B. Dumas, Dawn M. Carone, L. L. Hall, J. B. Lawrence
Biology Faculty Works
XIST RNA triggers chromosome-wide gene silencing and condenses an active chromosome into a Barr body. Here, we use inducible human XIST to examine early steps in the process, showing that XIST modifies cytoarchitecture before widespread gene silencing. In just 2–4 h, barely visible transcripts populate the large “sparse zone” surrounding the smaller “dense zone”; importantly, density zones exhibit different chromatin impacts. Sparse transcripts immediately trigger immunofluorescence for H2AK119ub and CIZ1, a matrix protein. H3K27me3 appears hours later in the dense zone, which enlarges with chromosome condensation. Genes examined are silenced after compaction of the RNA/DNA territory. Insights into this come …
Comparative Toxicity Assessment Of Glyphosate And Two Commercial Formulations In The Planarian Dugesia Japonica, S. Grace Fuselier , '25, Danielle Ireland, Nicholas Fu , '25, Christina Rabeler, Eva-Maria S. Collins
Comparative Toxicity Assessment Of Glyphosate And Two Commercial Formulations In The Planarian Dugesia Japonica, S. Grace Fuselier , '25, Danielle Ireland, Nicholas Fu , '25, Christina Rabeler, Eva-Maria S. Collins
Biology Faculty Works
Introduction: Glyphosate is a widely used, non-selective herbicide. Glyphosate and glyphosate-based herbicides (GBHs) are considered safe for non-target organisms and environmentally benign at currently allowed environmental exposure levels. However, their increased use in recent years has triggered questions about possible adverse outcomes due to low dose chronic exposure in animals and humans. While the toxicity of GBHs has primarily been attributed to glyphosate, other largely unstudied components of GBHs may be inherently toxic or could act synergistically with glyphosate. Thus, comparative studies of glyphosate and GBHs are needed to parse out their respective toxicity. Methods: We performed such a comparative …
Adult And Regenerating Planarians Respond Differentially To Chronic Drug Exposure, Kevin Bayingana , '23, Danielle Ireland, Elizabeth Rosenthal , '23, Christina Rabeler, Eva-Maria S. Collins
Adult And Regenerating Planarians Respond Differentially To Chronic Drug Exposure, Kevin Bayingana , '23, Danielle Ireland, Elizabeth Rosenthal , '23, Christina Rabeler, Eva-Maria S. Collins
Biology Faculty Works
There is a lack of data on the effects of chronic exposure to common drugs and stimulants on the developing nervous system. Freshwater planarians have emerged as a useful invertebrate model amenable to high-throughput behavioral phenotyping to assay chemical safety in adult and developing brains. Here, we leverage the unique strength of the system to test in parallel for effects on the adult and developing nervous system, by screening ten common drugs and stimulants (forskolin, clenbuterol, LRE-1, MDL-12,330A, adenosine, caffeine, histamine, mianserin, fluoxetine and sertraline) using the asexual freshwater planarian Dugesia japonica. The compounds were tested up to 100 …
Process Epistemologies For The Careful Interplay Of Art And Biology: An Afterword, S. R. Gilbert, Scott F. Gilbert
Process Epistemologies For The Careful Interplay Of Art And Biology: An Afterword, S. R. Gilbert, Scott F. Gilbert
Biology Faculty Works
No abstract provided.
Multilevel Selection On Social Network Traits Differs Between Sexes In Experimental Populations Of Forked Fungus Beetles, R. A. Costello, P. A. Cook, E. D. Brodie Iii, Vincent A. Formica
Multilevel Selection On Social Network Traits Differs Between Sexes In Experimental Populations Of Forked Fungus Beetles, R. A. Costello, P. A. Cook, E. D. Brodie Iii, Vincent A. Formica
Biology Faculty Works
Both individual and group behavior can influence individual fitness, but multilevel selection is rarely quantified on social behaviors. Social networks provide a unique opportunity to study multilevel selection on social behaviors, as they describe complex social traits and patterns of interaction at both the individual and group levels. In this study, we used contextual analysis to measure the consequences of both individual network position and group network structure on individual fitness in experimental populations of forked fungus beetles (Bolitotherus cornutus) with two different resource distributions. We found that males with high individual connectivity (strength) and centrality (betweenness) had …
Foreword: Symbiotic Perspectives On The Processes Of Biology And Art, Scott F. Gilbert
Foreword: Symbiotic Perspectives On The Processes Of Biology And Art, Scott F. Gilbert
Biology Faculty Works
No abstract provided.